|1.||Zajac, Jean-Marie: 10 articles (05/2014 - 12/2002)|
|2.||Mollereau, Catherine: 9 articles (11/2014 - 03/2005)|
|3.||Wang, Rui: 9 articles (09/2013 - 10/2007)|
|4.||Fang, Quan: 9 articles (09/2013 - 10/2007)|
|5.||Panula, Pertti: 5 articles (05/2006 - 03/2004)|
|6.||Moulédous, Lionel: 4 articles (05/2014 - 08/2008)|
|7.||Guo, Jia: 4 articles (04/2011 - 10/2007)|
|8.||Roumy, Michel: 4 articles (01/2011 - 03/2005)|
|9.||Jhamandas, Jack H: 4 articles (01/2011 - 06/2002)|
|10.||Zajac, J M: 4 articles (05/2001 - 01/2000)|
01/01/2003 - "The results of this study demonstrate a coordinated involvement of the spinal NPFF system in the persistent nociceptive pain states. "
06/01/2002 - "Since its physiological role has not yet been fully elucidated, the present study examined whether antisense peptide nucleic acid (PNA) complementary to the NPFF precursor (proNPFF(A)) modified pain sensitivity. "
01/01/1997 - "This study provides evidence for the presence of NPFF in human brain, but does not support the hypothesis that chronic pain is a consequence of elevated production of NPFF."
03/01/1996 - "Although clear antiopioid-like effects of NPFF on pain have been observed, some studies have also demonstrated long-lasting analgesic effects. "
08/01/2012 - "NPFF system has been reported to play important roles in pain transmission. "
11/13/2014 - "Testing of 46 alone was without effect in the mouse 48 °C warm-water tail-withdrawal test, but pretreatment with 46 prevented NPFF-induced hyperalgesia."
07/01/2010 - "Treatment with FF1 antagonists reversed established mechanical allodynia, indicating the possibility of increased NPFF tone through FF1 receptors. "
09/01/1998 - "The results indicate that neuropeptide FF in the periaqueductal gray may produce a selective attenuation of tactile allodynia in neuropathic rats. "
09/01/1998 - "Neuropeptide FF produced in a non-monotonic fashion a significant attenuation of tactile allodynia. "
11/03/2000 - "Neuropeptide FF attenuates allodynia in models of chronic inflammation and neuropathy following intrathecal or intracerebroventricular administration."
|3.||Neuralgia (Stump Neuralgia)
03/01/2004 - "NPFF displays multiple effects on acute, inflammatory and neuropathic pain. "
11/03/2000 - "or i.c.v. Neuropeptide FF in rats experiencing inflammatory, but not neuropathic pain. "
11/03/2000 - "Experiments were conducted to explore the effects of Neuropeptide FF acting at spinal and supraspinal sites in models of chronic inflammatory or neuropathic pain and of acute pain. "
11/03/2000 - "Furthermore, the results suggest that the anti-allodynic effect of Neuropeptide FF is mediated indirectly by naloxone-sensitive opioid mechanisms in rats subjected to inflammatory, but not neuropathic pain."
07/01/1999 - "These results show a different efficacy of 1DMe according to the pain model used, suggesting that the pro-opioid effects of the NPFF in neuropathic pain are only weak, which should contribute to hyperalgesia and to the impaired efficacy of morphine."
|4.||Opioid-Related Disorders (Opiate Addiction)
01/01/1999 - "These results clearly indicate that modulation of the NPFF system in the mammalian central nervous system has significant effects on opiate dependence. "
07/01/1996 - "Considerable evidence suggests that neuropeptide FF, an endogenous antiopiate peptide, contributes to opiate dependence. "
09/01/1991 - "The octapeptide FLFQPQRFamide (neuropeptide FF or F8Fa) may play a role in opiate dependence and subsequent abstinence syndrome. "
01/01/1995 - "Changes in CNS neuropeptide FF-like material, pain sensitivity, and opiate dependence following chronic morphine treatment."
11/09/1992 - "Previous studies suggest that neuropeptide FF (NPFF) plays a role in opiate dependence and subsequent abstinence syndrome. "
07/01/2008 - "These results suggest that NPFF receptors activation is required for opioid to produce hypothermia. "
07/01/2008 - "The selective NPFF receptors antagonist RF9 (30nmol) injected into the third ventricle failed to induce significant effect, but it completely antagonized the hypothermia of NPFF (45 nmol) after cerebral administration in mice. "
10/01/1997 - "In a thermoneutral environment, administration of NPFF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2), 1DMe ([D.Tyr1, (N.Me)Phe3] NPFF), and 3D ([D.Tyr1, D.Leu2, D.Phe3] NPFF) in the third ventricle produced marked hypothermia. "
04/10/2008 - "The present study examined the effects of RF9 on the hypothermia and anti-morphine action induced by NPFF in mice. "
07/01/2008 - "Both opioid and NPFF systems played important roles in thermoregulation, which suggested a link between opioid receptors and NPFF receptors in the production of hypothermia. "
|1.||Morphine (MS Contin)
|2.||Opioid Analgesics (Opioids)
|3.||phenylalanyl- leucyl- phenylalanyl- glutaminyl- prolyl- glutaminyl- arginyl- phenylalaninamide
|4.||Messenger RNA (mRNA)
|5.||Prolactin-Releasing Hormone (Prolactin Releasing Hormone)
|7.||3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)
|9.||Opioid Receptors (Opioid Receptor)