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temarotene
RN given refers to cpd without isomeric designation
Also Known As:
1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl)-2-(phenylethenyl)naphthalene; Ro 15-0778; temarotene, (E)-isomer
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Terpenes: 1461
Carotenoids: 4095
Retinoids: 5957
temarotene: 7
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclohexanes: 3
Cyclohexenes: 4
Carotenoids: 4095
Retinoids: 5957
temarotene: 7
Acyclic Hydrocarbons
Alkenes: 265
Polyenes: 164
Carotenoids: 4095
Retinoids: 5957
temarotene: 7
Biological Factors: 2472
Biological Pigments: 1
Carotenoids: 4095
Retinoids: 5957
temarotene: 7
Related Diseases
1.
Lichen Planus (Lichen Ruber Planus)
10/21/1989 - "
Treatment of lichen planus with temarotene.
"
04/01/1994 - "
Many groups have used different drugs in the treatment of lichen planus: topically applied retinoic acid, temarotene, antimycotic agents corticosteroids and immunosuppressive agents, with unsatisfactory results.
"
2.
Hypervitaminosis A
07/01/1988 - "
No signs or symptoms of hypervitaminosis A were noted with Ro 15-0778.
"
01/01/1988 - "
The nonpolar arotinoid Ro 15-0778 [(E)-1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethen yl) naphthalene] does not contain a polar end group and is devoid of the classical retinoid side effects of hypervitaminosis A.
"
3.
Carcinoma (Carcinomatosis)
07/01/1988 - "
The present investigation underlines the fact that the arotinoid Ro 15-0778 is not only a chemopreventive agent but also exerts a chemotherapeutic effect on established, chemically induced, mammary carcinomas of the rat.
"
07/01/1988 - "
Therapeutic effect of the arotinoid Ro 15-0778 on chemically induced rat mammary carcinoma.
"
01/01/1990 - "
Sebocytes are not responsive to the arotinoid temarotene, which is active in the aforementioned animal models and against dimethylbenz[a]anthracene (DMBA)-induced rat mammary carcinoma but inactive clinically in acne.
"
4.
Acne Vulgaris
10/01/1987 - "
Another arotinoid, the parent compound Ro 15-0778, has not demonstrated any convincing clinical efficacy in acne or psoriasis, but topical anti-inflammatory effects were evident in some models.(ABSTRACT TRUNCATED AT 400 WORDS)
"
01/01/1990 - "
Sebocytes are not responsive to the arotinoid temarotene, which is active in the aforementioned animal models and against dimethylbenz[a]anthracene (DMBA)-induced rat mammary carcinoma but inactive clinically in acne.
"
5.
Psoriasis (Pustulosis Palmaris et Plantaris)
10/01/1987 - "
Another arotinoid, the parent compound Ro 15-0778, has not demonstrated any convincing clinical efficacy in acne or psoriasis, but topical anti-inflammatory effects were evident in some models.(ABSTRACT TRUNCATED AT 400 WORDS)
"
Related Drugs and Biologics
1.
Retinoids
2.
Therapeutic Uses
3.
Tretinoin (Retinoic Acid)
4.
Immunosuppressive Agents (Immunosuppressants)
5.
Adrenal Cortex Hormones (Corticosteroids)
6.
retinamide
7.
anthracene
8.
naphthalene