HLA-Dw4 antigen

07/01/1978 - "In independent studies, 51% and 36% of patients with rheumatoid arthritis have been shown to possess HLA-Dw4 compared to 7% and 13% of controls. "
02/01/1995 - "HLA-Dw4 association with rheumatoid arthritis: comment on the article by Nelson et al."
01/01/1984 - "Patients admitted to a prospective study within a year of onset of suspected rheumatoid arthritis showed a positive correlation between HLA-Dw4 and the eventual severity of peripheral radiologic changes. "
05/01/1981 - "Stastny, however, showed a significantly high frequency of HLA-Dw4 in rheumatoid arthritis in 1976. "
06/01/1977 - "Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis."

04/30/1988 - "Beside the classic association HLA B27-ankylosing spondylitis, recent studies have demonstrated an anomaly high frequency of HLA-DW4 and HLA-DR4 in patients with rheumatoid polyarthritis as compared to a reference population. "
01/01/1979 - "HLA-DW4, the antigen found in previous studies to characterize adult rheumatoid arthritis, had a significantly lower frequency in children with arthritis than in normal controls (P less than 0.04). "

04/30/1988 - "Beside the classic association HLA B27-ankylosing spondylitis, recent studies have demonstrated an anomaly high frequency of HLA-DW4 and HLA-DR4 in patients with rheumatoid polyarthritis as compared to a reference population. "

07/01/1989 - "Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant."

09/01/1989 - "However, the rheumatoid arthritis disease susceptibility determinant on the beta-1 chain of individuals with the HLA Dw4, Dw14 or DR1 haplotypes is reproduced by the gp110 protein of the Epstein-Barr virus, and is a potent stimulus for T cell proliferation. "