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4-des-dimethylaminotetracycline
non-antibacterial, inhibits mammalian collagenase; RN given refers to (4aS-(4aalpha,5aalpha,6beta,12aalpha))-isomer
Also Known As:
4-de-dimethylaminotetracycline; 4-dedimethylaminotetracycline; CMT-1; DDA-tetracycline
Networked:
9
relevant articles (
0
outcomes,
3
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Tetracyclines: 1162
Tetracycline: 5654
4-des-dimethylaminotetracycline: 9
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Tetracyclines: 1162
Tetracycline: 5654
4-des-dimethylaminotetracycline: 9
Experts
1.
Harms, Matthew B
: 1 article (12/2013)
2.
Pestronk, Alan
: 1 article (12/2013)
3.
Zaidman, Craig M
: 1 article (12/2013)
Related Diseases
1.
Chronic Periodontitis
01/01/1992 - "
In the present study, doxycycline (a clinically widely used commercial tetracycline) and 4-de-dimethylaminotetracycline (CMT-1, a chemically modified non-antimicrobial tetracycline) were tested, at a wide range of concentrations, for their ability to inhibit human neutrophil and fibroblast interstitial collagenases, which are distinct gene products, as well as collagenase in human gingival crevicular fluid (an inflammatory exudate in periodontal lesions) obtained from adult, juvenile and diabetic adult periodontitis patients.
"
2.
Neoplasms (Cancer)
01/30/2023 - "
CMT-1 cell line was obtained from a canine mammary tumor CMT-1 and characterized molecularly through qPCR, western blotting, immunochemistry and immunofluorescence.
"
01/30/2023 - "
Inoculation of CMT-1 cells induced a complex HER2-enriched mammary tumor with metastasis in mice.
"
01/30/2023 - "
In this study, a CMT-1 cell line obtained from CMT-1 tumor was immune-positive to vimentin, α-SMA, p63 and negative to E-cadherin (E-cad), indicating CMT-1 cells were myoepithelial cells.
"
01/30/2023 - "
CMT-1 tumor was a complex canine mammary carcinoma that stained negative to estrogen receptors (ER) and progesterone receptors (PR), but positive to human epidermal growth receptor-2 (HER2), defined as HER2-enriched subtype.
"
3.
Infections
01/01/1998 - "
The PGI group showed little hybridization in the areas of infection, while both the DOXY and CMT-1 groups showed co-expression of the alpha2(I) and alpha1(XII) probes in the GCT and coronal part of the PDL.
"
01/01/1998 - "
This study demonstrates that doxycycline and CMT-1 moderate or reduce the inhibitory effects of periodontal infection on the expression of type I and type XII collagen mRNAs.
"
4.
Aggressive Periodontitis (Periodontosis)
04/01/1992 - "
The drug concentration required to inhibit 50% of collagenase activity (IC50) in localized juvenile periodontitis gingival crevicular fluid was 280 microM for doxycycline and 470 microM for 4-de-dimethylaminotetracycline.
"
01/01/1992 - "
In contrast, the fibroblast collagenase and collagenase in gingival crevicular fluid of patients with juvenile periodontitis were relatively resistant to tetracycline inhibition: the IC50 for doxycycline and CMT-1 were 280 and 500 microM, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
"
5.
Neoplasm Metastasis (Metastasis)
01/30/2023 - "
Inoculation of CMT-1 cells induced a complex HER2-enriched mammary tumor with metastasis in mice.
"
04/01/1998 - "
Furthermore, data derived from the in vivo model indicate that SCID mice dosed orally with CMT-1 or CMT-3 contained a reduced number of lung metastases following i.v. injection of C8161 cells via tail vein inoculation.
"
Related Drugs and Biologics
1.
Doxycycline (Periostat)
2.
Collagenases (Collagenase)
3.
Collagen Type XII
4.
Cadherins (E-Cadherin)
5.
Vimentin
6.
Tetracycline (Achromycin)
7.
Matrix Metalloproteinase Inhibitors
8.
Matrix Metalloproteinase 8 (Neutrophil Collagenase)
9.
Matrix Metalloproteinases (MMPs)
10.
Progesterone Receptors (Progesterone Receptor)