annonacin

12/10/2020 - "EAB extract was then standardized for annonacin content using High-performance Liquid Chromatography - Mass Spectrometry (HPLC-MS) and shown to be effective against a second prostate cancer cell line (DU-145) also. "
12/10/2020 - "Ethnomedically used plant parts, were examined in this study against human prostate cancer cells for the first time and mechanisms of action elucidated for the most potent of them, along with the active phytochemical, annonacin. "

01/01/2023 - "We report that Annonacin A binds at a greater affinity with ABCB1 and might act as a potential drug lead to reverse MDR in tumor cells. "
09/20/2022 - "Retraction Note: Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways."
01/01/2018 - "Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways."
10/11/2011 - "In nude mice, annonacin decreased MCF-7 xenograft tumor size at 7-22 days. "
05/09/2003 - "In summary, these results suggest that annonacin is potentially a promising anti-cancer compound."

10/11/2011 - "Thus, we studied the effects of annonacin, an annonaceous acetogenin, in breast cancer cells. "
11/01/2022 - "Collectively, this study demonstrated the effectiveness of nanodiamonds as a carrier of annonacin to inhibit breast cancer cell growth through inhibition of the PI3K/Akt signaling pathway."
11/01/2022 - "In this study, we aimed to investigate the potency of nanodiamonds to be employed as a carrier of annonacin to help increase its viability and inhibit the growth of breast cancer cells. "
11/01/2022 - "Increasing the effect of annonacin using nanodiamonds to inhibit breast cancer cells growth in rats (Rattus norvegicus)-Induced breast cancer."
07/01/1991 - "The cytotoxicities in vitro of annomontacin [I], annonacinone [2], and annonacin were measured against murine leukemia L1210, human breast adenocarcinoma MDA-MB231, and human breast carcinoma MCF7 cell lines and compared with adriamycin."

09/03/2019 - "Therefore, this study was aimed to investigate antitumor-promoting activity of annonacin via in vivo two-stage mouse skin tumorigenesis model and its molecular pathways involved. "
09/03/2019 - "Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin."
09/03/2019 - "Significant modulation of both AKT, ERK, mTOR, p38, PTEN and Src genes and proteins were also observed in annonacin-targeted signaling pathway(s) against tumorigenesis. "
09/03/2019 - "Collectively, results of this study indicate that annonacin is a potential therapeutic compound targeting tumor promoting stage in skin tumorigenesis by modulating multiple gene and protein in cancer signaling pathways without apparent toxicity."

10/01/2017 - "We aimed to study the antitumor activity of annonacin and its mechanism of action in endometrial cancer cells. "
10/01/2017 - "Our data represented that annonacin could be an alternative therapeutic treatment to combat endometrial cancer. "
10/01/2017 - "Annonacin exerted antiproliferation effects on both endometrial cancer cell lines and primary cells via induction of apoptosis and inhibition of extracellular signal-regulated kinase. "