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U 74500A

potent inhibitor of iron-dependent lipid peroxidation; has excellent activity in in vivo models of experimental CNS trauma & ischemia; structure given in first source; RN given is for 3,6-bis(diethylamino) cpd; Cancer Lett 1992;64(1):61-6 uses 5,6-bis(diethylamino) cpd for U 74500A
Also Known As:
21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl; 21-(4-(5,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl; U 74500E; U-74500A; U-74500E; U74500; U74500A; U74500E; Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methyl-, hydrochloride, (16alpha)-
Networked: 17 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Chopra, K: 1 article (11/2007)
2. Kulkarni, S K: 1 article (11/2007)
3. Bishnoi, M: 1 article (11/2007)
4. Hsu, Kang: 1 article (08/2004)
5. Wang, David: 1 article (08/2004)
6. Lin, Hen-I: 1 article (08/2004)
7. Chu, Shi-Jye: 1 article (08/2004)
8. Chang, Deh-Ming: 1 article (08/2004)
9. Lin, Shih-Hua: 1 article (08/2004)
10. Satyanarayana, Padi S V: 1 article (03/2003)

Related Diseases

1. Reperfusion Injury
2. Acute Lung Injury
3. Ischemia
4. Lung Injury
5. Myocardial Ischemia (Ischemic Heart Diseases)

Related Drugs and Biologics

1. Tetradecanoylphorbol Acetate
2. Superoxide Dismutase
3. Catalase
4. 1,3-dimethylthiourea
5. Iron
6. U 74389F
7. U 78517F
8. Citric Acid (Citrate)
9. Thiobarbituric Acid Reactive Substances
10. Sodium Nitrite

Related Therapies and Procedures

1. Warm Ischemia
2. Heart Transplantation (Grafting, Heart)
3. Homologous Transplantation (Allograft)
4. Intravenous Injections