U 74500A

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19 relevant articles (0 outcomes, 2 trials/studies) found for this Bio-Agent

Description: potent inhibitor of iron-dependent lipid peroxidation; has excellent activity in in vivo models of experimental CNS trauma & ischemia; structure given in first source; RN given is for 3,6-bis(diethylamino) cpd; Cancer Lett 1992;64(1):61-6 uses 5,6-bis(diethylamino) cpd for U 74500A

Also Known As:

21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl; 21-(4-(5,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)triene-3,20-dione HCl; U 74500E; U-74500A; U-74500E; U74500; U74500A; U74500E; Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(3,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methyl-, hydrochloride, (16alpha)-

Bio-Agent Context: Research Results

Polycyclic Compounds: 58

Experts

1.	Chopra, K: 1 article (11/2007)
2.	Bishnoi, M: 1 article (11/2007)
3.	Kulkarni, S K: 1 article (11/2007)
4.	Hsu, Kang: 1 article (08/2004)
5.	Chang, Deh-Ming: 1 article (08/2004)
6.	Chu, Shi-Jye: 1 article (08/2004)
7.	Lin, Shih-Hua: 1 article (08/2004)
8.	Lin, Hen-I: 1 article (08/2004)
9.	Wang, David: 1 article (08/2004)
10.	Chopra, Kanwaljit: 1 article (03/2003)

Related Diseases

1.	Reperfusion Injury 03/01/2003 - "The aim of the present study was to investigate the effects of the synthetic antioxidant U-74500A, a 21-aminosteroid in a rat model of renal ischemia-reperfusion injury" 03/01/2003 - "These results clearly demonstrate the in vivo antioxidant effect of U-74500A, a 21-aminosteroid in attenuating renal ischemia-reperfusion injury." 03/01/2003 - "Effect of U-74500A, a 21-aminosteroid on renal ischemia-reperfusion injury in rats." 10/01/1996 - "BACKGROUND: The lazaroid U74500A is a 21-aminosteroid that inhibits lipid peroxidation and attenuates ischemia-reperfusion injury" 01/27/1996 - "The heart pretreated with U74500A showed less ischemia-reperfusion injury, better ventricular function, and a lower lipid peroxide level" Get all the results and reference details, order at left...
2.	Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 08/01/2004 - "Protective effect of U74500A on phorbol myristate acetate-induced acute lung injury." 08/01/2004 - "1. The present study was designed to determine whether U74500A could ameliorate acute lung injury (ALI) induced by phorbol myristate acetate (PMA) in our rat isolated lung model compared with any amelioration induced by dimethylthiourea (DMTU), superoxide dismutase (SOD) and catalase" Get all the results and reference details, order at left...
3.	Ischemia 01/01/1996 - "CONCLUSIONS: The administration of U74500A prevented lipid peroxidation and preserved pulmonary allograft function after 24 hours of ischemia." 03/01/2003 - "U-74500A markedly attenuated elevated levels of TBARS as well as morphological changes, but did not improve renal dysfunction in rats subjected to renal ischemia-reperfusion" 04/01/1997 - "A lazaroid compound, U74500A, or a citrate vehicle was given intravenously to each of the six animals for 30 minutes before intestinal ischemia" 11/01/1996 - "Because lipid peroxidation may cause cell membrane injury after ischemia and reperfusion, we hypothesized that the administration of a lipid peroxidation inhibitor lazaroid (U74500A) would result in an improvement of functional recovery after the 24-hour preservation period" 11/01/1996 - "The purpose of these experiments was to evaluate the capacity of the lazaroids U-74500A and U-74389F to modify ischemia/reperfusion injury of skeletal muscle in a well-characterized model of high-grade partial ischemia" Get all the results and reference details, order at left...
4.	Dyskinesias (Dyskinesia) 11/01/2007 - "U-74500A, an aminosteroid, may have therapeutic use in typical neuroleptic-induced tardive dyskinesia-like effects." Get all the results and reference details, order at left...
5.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/1994 - "Reduction of infarct size during myocardial ischemia and reperfusion by lazaroid U-74500A, a nonglucocorticoid 21-aminosteroid." Get all the results and reference details, order at left...
15 Diseases and 19 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Tetradecanoylphorbol Acetate
2.	Superoxide Dismutase
3.	Catalase
4.	1,3-dimethylthiourea
5.	Iron (Serum Iron Level)
6.	U 74389F
7.	U 78517F
8.	Citric Acid (Citrate)
9.	Thiobarbituric Acid Reactive Substances
10.	Sodium Nitrite
26 Drugs and Important Bio-Agents and 14 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Warm Ischemia
2.	Heart Transplantation (Grafting, Heart)
3.	Homologous Transplantation (Allograft)
3 Therapies and Procedures and 3 more articles analyzed in the Research Interface, order at left...

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