FR 900482

isolated from Streptomyces sandaensis; structure given in above source

Also Known As:

4-formyl-6,9-dihydroxy-14-oxa-1,11-diazatetracyclo(7.4.1.O(2,7).O(10,12))tetradeca-2,4,6-triene-8-ylmethyl carbamate; FR-900482; FR900482; 3,9-Epoxy-3H-azirino(2,3-c)(1)benzazocine-5-carboxaldehyde, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,9,9a-hexahydro-7,9-dihydroxy-

Networked: 8 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - FR 900482: 8

Experts

1.	O'Boyle, Brendan M: 2 articles (07/2011 - 04/2008)
2.	Trost, Barry M: 2 articles (07/2011 - 04/2008)
3.	Jain, Duli C: 2 articles (11/2007 - 01/2007)
4.	Sapse, Anne-Marie: 2 articles (11/2007 - 01/2007)
5.	Ameriks, Michael K: 1 article (07/2011)
6.	Torres, Wildeliz: 1 article (07/2011)
7.	Hernandez, Gabriel A: 1 article (11/2007)
8.	Rothchild, Robert: 1 article (11/2007)
9.	Beckerbauer, Lois: 1 article (04/2002)
10.	Eastman, Rebecca A: 1 article (04/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2007 - "Hartree-Fock and density functional theory (B3LYP) calculations were applied to the study of the anti-tumor drug FR900482 and some of its analogs. " 11/01/2007 - "Theoretical studies of the anti-tumor drug FR900482." 01/01/2007 - "Theoretical studies of the reduction reaction of the anti-tumor drug FR900482." 04/03/2008 - "Herein, we report synthesis and biological testing of 7-Epi (+)-FR900482, which demonstrates equal potency relative to the natural product against several cancer cell lines. " 04/03/2008 - "Synthesis of 7-Epi +-FR900482: an epimer of comparable anti-cancer activity."
2.	Necrosis 04/01/2002 - "We demonstrate that, whereas FR900482 induces necrosis, FK317 induces a necrosis-to-apoptosis switch that is drug concentration dependent. "

Related Drugs and Biologics

1.	Oncogene Proteins (Oncogene Protein)
2.	DNA (Deoxyribonucleic Acid)
3.	Antineoplastic Agents (Antineoplastics)
4.	Trientine (Trien)
5.	Anti-Bacterial Agents (Antibiotics)
6.	FK 973
7.	Mitomycin (Mitomycin-C)
8.	Proteins (Proteins, Gene)
9.	7-epi-FR900482
10.	LC 6