N-homocysteine thiolactonyl retinamide
causes human platelet aggregation
Also Known As:
NHCTR; thioretinamide
Networked: 7
relevant articles (0 outcomes,
2 trials/studies)
Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Atherosclerosis
08/01/1990
- " Homocysteine and lipid metabolism in atherogenesis: effect of the homocysteine thiolactonyl derivatives, thioretinaco and thioretinamide." 08/01/1990
- " Facilitation of atherogenesis is attributed to the effect of homocysteine on artery wall, either from parenteral homocysteine or from the increased synthesis of homocysteine from methionine, produced by thioretinaco and thioretinamide." 12/01/2016
- " These proposed reactions for PAPS synthesis in atherosclerosis explain the metabolic pathway for formation of PAPS from homocysteine through the intermediate formation of thioretinamide (TR) and explain how hyperhomocysteinemia stimulates production of sulfated glycosaminoglycans (GAG), which are essential components of atherosclerotic plaques." 08/01/1990
- " In order to study the relation of homocysteine and lipid metabolism to atherogenesis, rabbits were fed a synthetic atherogenic diet and treated with parenteral thioretinaco (N-homocysteine thiolactonyl retinamido cobalamin), thioretinamide (N-homocysteine thiolactonyl retinamide) or homocysteine thiolactone hydrochloride. " 10/18/2016
- " Depletion of adenosyl methionine causes dysregulation of methionine metabolism, hyperhomocysteinemia, reduced biosynthesis of thioretinamide and thioretinaco ozonide, decreased oxidative phosphorylation, decreased production of nitric oxide and peroxynitrite, and impaired host response to infectious microbes, contributing to the pathogenesis of dementia and atherosclerosis."
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2. | Protein-Energy Malnutrition (Marasmus)
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3. | Carcinogenesis
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4. | Hyperhomocysteinemia
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5. | Neoplasms (Cancer)
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