|1.||Melanoma (Melanoma, Malignant)
05/01/1985 - "In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells."
05/01/1985 - "2,4-Dihydroxyphenylalanine proved to be cytotoxic to both B-16 and Cloudman melanoma cells in vitro. "
04/29/1987 - "Since 2,4-DOPA is a potential pro-drug for melanoma chemotherapy, further evaluation of its neurobiologic properties is needed."
05/01/1985 - "These results show that 2,4-dihydroxyphenylalanine is toxic to melanoma cells and that activation of 2,4-dihydroxyphenylalanine requires the presence of tyrosinase."
05/01/1985 - "We have evaluated the chemotherapeutic potential of 2,4-dihydroxyphenylalanine, a targeted prodrug that can be hydroxylated by tyrosinase (monophenol monooxygenase, EC 126.96.36.199) within melanoma cells to form the cellular toxin 2,4,5-trihydroxyphenylalanine (6-hydroxydopa). "
|1.||Monophenol Monooxygenase (Tyrosinase)
|1.||Drug Therapy (Chemotherapy)