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KP 136
RN given refers to parent cpd
Also Known As:
8-hexyloxy-3-(1H-tetrazol-5-yl)-2H-chromen-2-one; KP 136, potassium salt; KP 136, sodium salt; KP-136; 2H-1-Benzopyran-2-one, 8-(hexyloxy)-3-(1H-tetrazol-5-yl)-
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Tetrazoles: 14
KP 136: 4
Pyrans: 130
Benzopyrans: 195
Chromones: 159
KP 136: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
KP 136: 4
Related Diseases
1.
Hypersensitivity (Allergy)
03/01/1990 - "
The pharmacological properties of KP-136, an inhibitor of type I allergy, were studied in rat paw models.
"
03/01/1990 - "
In four allergic responses, three of the immediate type and one delayed type, KP-136 (p.o.) produced potent inhibitions on the mast cell-mediated type I allergy (ID30: 1.0 mg/kg) and the neutrophil-infiltrated passive Arthus reaction (ID30: 1.6 mg/kg).
"
04/01/1987 - "
In four rat cutaneous reactions produced by three allergic reactions and compound 48/80, KP-136 was remarkably effective on two homologous PCA induced by IgE and IgGa.
"
2.
Hemolysis
12/01/1988 - "
KP-136 also inhibited A23187- and heat-induced degranulation and heat-induced hemolysis.
"
03/01/1990 - "
Although KP-136 was a weak inhibitor of carrageenin-induced paw edema, prostaglandin synthesis and complement-mediated hemolysis, the compound inhibited the release of lysosomal enzymes such as lysozyme and beta-glucuronidase in the passive Arthus reaction, suggesting the blockage of inflammatory mediator release for its mode of action.
"
3.
Inflammation (Inflammations)
03/01/1990 - "
In addition, KP-136 (10 mg/kg, 50 mg/kg, p.o.) inhibited the injury of bone tissues in rat adjuvant arthritis, confirming that it was effective on the allergic inflammation with tissue injury.
"
4.
Edema (Dropsy)
03/01/1990 - "
[Effect of KP-136 on allergic paw edema in the rat].
"
03/01/1990 - "
Although KP-136 was a weak inhibitor of carrageenin-induced paw edema, prostaglandin synthesis and complement-mediated hemolysis, the compound inhibited the release of lysosomal enzymes such as lysozyme and beta-glucuronidase in the passive Arthus reaction, suggesting the blockage of inflammatory mediator release for its mode of action.
"
5.
Asthma (Bronchial Asthma)
03/01/1989 - "
KP-136 (1 mg/kg, i.v.) was also effective on allergic asthma of guinea pigs, although DSCG was ineffective even at a high dose of 50 mg/kg (i.v.).
"
03/01/1989 - "
KP-136 (0.125-1 mg/kg i.v., 0.5-2 mg/kg p.o.) produced a dose-dependent inhibition to allergic asthma of rats and was more potent than DSCG (1-5 mg/kg i.v.).
"
03/01/1989 - "
Effect of 8-hexyloxy-3-(1H-tetrazol-5-yl)-2H-chromen-2-one [KP-136] on experimental asthma: a comparison with disodium cromoglycate.
"
03/01/1989 - "
In rats, both KP-136 and DSCG significantly blocked the reduction of histamine content of the trachea after allergic asthma and inhibited the antigen-induced histamine release from lung fragments (KP-136 0.5 micrograms/ml, DSCG 50 micrograms/ml) and peritoneal exudate cells (KP-136 0.1 micrograms/ml, DSCG 10 micrograms/ml).
"
03/01/1989 - "
The pharmacological properties of 8-hexyloxy-3-(1H-tetrazol-5-yl)-2H-chromen-2-one, KP-136 were compared with those of an antiallergic medicament, disodium cromoglycate (DSCG) in experimental asthma models.
"
Related Drugs and Biologics
1.
KP 136
2.
Anti-Allergic Agents (Antiallergic Agents)
3.
Prostaglandins
4.
Muramidase (Lysozyme)
5.
Immunoglobulin E (IgE)
6.
Histamine (Histamine Dihydrochloride)
7.
Glucuronidase
8.
Enzymes
9.
Cromolyn Sodium (Cromoglicic Acid)
10.
p-Methoxy-N-methylphenethylamine