clausenamide

05/05/2012 - "It has been shown that (-)clausenamide, but not (+)clausenamide, improved learning and memory in amnesia animal models. "
09/01/2020 - "(-)-Clausenamide has been reported to be nootropic and improve learning and memory in amnesia animal models. "
11/01/1998 - "The protective action of (-)clausenamide against anisodine-induced amnesia is due to its ability to reverse the ACh reduction."
01/01/1998 - "The results indicate that there is significant difference between the actions of (-)clausenamide and (+)clausenamide; The protective action of (-)clausenamide against anisodine-induced amnesia is due to its ability to reverse ACh reduction."

03/01/2002 - "For example, anisodamine possesses good effects in the treatment of septic shock and morphine addiction; 3-n-butylphthalide isolated from seeds of celery was shown to be a new cerebral anti-ischemic agent; indirubin was identified as an anti-leukemic drug with no inhibition of bone marrow; huperzine is a potent and reversible inhibitor of acetylcholinesterase (AChE) and its selective action is superior to that of donepezil; clausenamide was shown to be a potassium channel blocker, its nootropic effect was 50-100 times more potent than that of piracetam; bicyclol was synthesized from schizandrin C isolated from Fructus schizandrae. "

03/01/2002 - "For example, anisodamine possesses good effects in the treatment of septic shock and morphine addiction; 3-n-butylphthalide isolated from seeds of celery was shown to be a new cerebral anti-ischemic agent; indirubin was identified as an anti-leukemic drug with no inhibition of bone marrow; huperzine is a potent and reversible inhibitor of acetylcholinesterase (AChE) and its selective action is superior to that of donepezil; clausenamide was shown to be a potassium channel blocker, its nootropic effect was 50-100 times more potent than that of piracetam; bicyclol was synthesized from schizandrin C isolated from Fructus schizandrae. "

11/01/1998 - "(-)Clausenamide ameliorated anisodine-induced memory deficits in step-through test in mice. "
01/01/1998 - "In the meantime, (-) clausenamide ameliorate anisodine-induced memory deficits in step-through test in mice. "
11/01/1998 - "To study the action mechanism of a new cognition enhancer clausenamide and the effect of clausenamide on regional acetylcholine (ACh) levels, and to examine anisodine-induced ACh decrease in mice of memory deficits, and to compare the effect of (-)clausenamide on ACh with that of (+)clausenamide. "
11/01/1998 - "Effects of clausenamide on anisodine-induced acetylcholine decrease and memory deficits in the mouse brain."
01/01/1998 - "The effect of a new cognition enhancer clausenamide on regional acetylcholine (ACh) levels and anisodine-induced ACh decrease were examined in mice of memory deficits. "

01/01/1998 - "With the extracellular recording technique, the basal synaptic responses (population spike, PS) evoked by low frequency test stimulation in the dentate gyrus of anesthetized rats was recorded and the effects of (-) and (+) clausenamide(icv) on the PS and long-term potentiation (LTP) induced by tetanus (50 pulses at 200 Hz) were observed. "
02/01/1999 - "I.c.v. injection of naloxone 1 nmol, affecting neither the basal PS amplitude nor the LTP induced by tetanus, reduced the l-clausenamide-potentiated LTP only when it was administrated prior to clausenamide. "