S-phenyl-N-acetylcysteine

found in urine of rats exposed to benzene; RN given refers to (L)-isomer; RN for cpd without isomeric designation not available 4/88

Also Known As:

2-acetamido-3-phenylthiopropanoic acid; S-phenyl-N-acetylcysteine, (DL)-isomer; S-phenylmercapturic acid; phenylmercapturic acid

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - Acetylcysteine: 4440
        S-phenyl-N-acetylcysteine: 9
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - Acetylcysteine: 4440
        S-phenyl-N-acetylcysteine: 9

Experts

1.	Waidyanatha, Suramya: 2 articles (02/2005 - 06/2003)
2.	Fan, Ruifang: 1 article (11/2020)
3.	Jiang, Wenhui: 1 article (11/2020)
4.	Kuang, Hongxuan: 1 article (11/2020)
5.	Li, Yonghong: 1 article (11/2020)
6.	Liu, Jian: 1 article (11/2020)
7.	Pang, Qihua: 1 article (11/2020)
8.	Tan, Jianhua: 1 article (11/2020)
9.	Wu, Peiqiong: 1 article (11/2020)
10.	Zeng, Yingwei: 1 article (11/2020)

Related Diseases

1.	Chromosome Aberrations (Chromosome Abnormalities) 01/15/2010 - "End-shift urine samples were collected for t,t-muconic acid (t,t-MA) determination by HPLC and for S-phenylmercapturic acid (S-PMA) measurement by HPLC-MS/MS. The alkaline version of the comet assay and, in a subgroup of 19 SSA and 16 control subjects, chromosomal aberrations (CA) and glutathione (GSH) levels were measured in peripheral blood lymphocytes. " 06/01/2003 - "The biomarkers evaluated were urinary metabolites S-phenylmercapturic acid (S-PMA*), trans,trans-muconic acid (t,t-MA), hydroquinone (HQ), catechol (CAT), and phenol; albumin adducts of benzene oxide and 1,4-benzoquinone (BO-Alb and 1,4-BQ-Alb, respectively) in blood; blood cell counts; and chromosomal aberrations. " 01/01/2019 - "Sociodemographic data on the workers were evaluated; the concentration of benzene/toluene (B/T) in atmospheric air and individual trans,trans-muconic acid (ttMA) and S-phenylmercapturic acid (S-PMA) were measured; oxidative stress was analyzed by catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), thiol groups (THIOL) and malondialdehyde (MDA); genotoxicity was measured by metaphases with chromosomal abnormalities (MCA) and nuclear abnormalities, comet assay using the enzyme formamidopyrimidine DNA glycosylase (C-FPG), and methylation of repetitive element LINE-1, CDKN2B and KLF6 genes. "
2.	Asthma (Bronchial Asthma) 11/01/2020 - "Furthermore, binary logistic regression showed that each unit increases in level of urinary 2-&3-hydroxyfluorene (2-&3-OHF), 2-hydroxyphenanthrene (2-OHPhe), 1-hydroxyphenanthrene (1-OHP) and S-phenylmercapturic acid (S-PMA) were significantly associated with an elevated risk of asthma in children with odds ratios of 1.5, 2.3, 1.7 and 1.4, respectively, suggesting that PAHs and BTs exposure could increase the risk of asthma for children. " 06/01/2013 - "Our aim was to relate urinary S-phenylmercapturic acid (S-PMA), a biomarker of benzene exposure, to benzene concentrations and related sources at home and asthma in a population-based sample of children. "
3.	Genetic Predisposition to Disease (Genetic Predisposition) 02/03/2011 - "An integrated approach based on environmental and biological monitoring, including the analysis of biomarkers of exposure [excretion of S-phenylmercapturic acid (S-PMA)], early biological effects [micronucleus (MN) frequency] and susceptibility (genetic polymorphisms), was applied to characterize benzene exposure in a group of 70 traffic policemen and 40 employees of the city of Bologna, Italy. "
4.	Lung Neoplasms (Lung Cancer) 01/01/2023 - "Using data from a subcohort of 2,309 current smokers at the time of urine collection from the Multiethnic Cohort Study, we prospectively evaluated the association of ten urinary biomarkers of smoking-related toxicants [total nicotine equivalents (TNE), a ratio of total trans-3'-hydroxycotinine (3-HCOT)/cotinine (a phenotypic measure of CYP2A6 enzymatic activity), 4-(methylnitrosamino)-1-3-(pyridyl)-1-butanol (NNAL), S-phenylmercapturic acid (SPMA), 3-hydroxypropyl mercapturic acid (3-HPMA), phenanthrene tetraol (PheT), 3-hydroxyphenanthrene (PheOH), the ratio of PheT/PheOH, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid (8-iso-PGF2α)] with lung cancer risk (n = 140 incident lung cancer cases over an average of 13.4 years of follow-up). "
5.	Hypertension (High Blood Pressure) 10/01/1997 - "Moreover, as hypertension might be associated with an increased excretion of nephrotoxic mercapturates, the association between blood pressure and urinary concentration of S-phenylmercapturic acid (S-PMA) was also examined. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Benzene (Benzole)
3.	muconic acid (cis,cis-muconate)
4.	Glutathione (Reduced Glutathione)
5.	Acetylcysteine (Siran)
6.	benzene oxide
7.	DNA-Formamidopyrimidine Glycosylase (Formamidopyrimidine DNA Glycosylase)
8.	Phenol (Carbolic Acid)
9.	Toluene
10.	Superoxide Dismutase