o-succinylbenzoic acid synthase
E coli enzyme; with SHCHC synthase catalyzes formation of o-succinylbenzoic acid from isochorismic acid & alpha-ketoglutarate in presence of thiamine pyropyrophosphate; succinic semialdehyde anion is formed by decarboxylation of alpha-ketoglutarate by thiamine pyrophosphate; anion then attacks isochorismic acid, initiating aromatization with elimination of pyruvate & H2O
Also Known As:
2-succinylbenzoic acid synthase; MenC protein, E coli; OSB synthase; o-succinylbenzoate synthase; ortho-succinylbenzoic acid synthase
Networked: 7
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Gerlt, John A:
4 articles
(04/2006 - 12/2003)
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2. | Rayment, Ivan:
3 articles
(05/2004 - 12/2003)
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3. | Taylor Ringia, Erika A:
3 articles
(05/2004 - 12/2003)
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4. | Garrett, James B:
2 articles
(05/2004 - 01/2004)
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5. | Holden, Hazel M:
2 articles
(05/2004 - 01/2004)
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6. | Thoden, James B:
2 articles
(05/2004 - 01/2004)
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7. | Fling, Russell R:
1 article
(11/2021)
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8. | Zacharewski, Timothy R:
1 article
(11/2021)
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9. | Raushel, Frank M:
1 article
(04/2006)
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10. | Sakai, Ayano:
1 article
(04/2006)
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Related Diseases
1. | Dehydration (Water Stress)
05/18/2004
- " This phenomenon has been suggested to occur in the o-succinylbenzoate synthase (OSBS) from a species of Amycolatopsis that catalyzes not only the physiological syn-dehydration reaction of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate but also an accidental racemization of N-acylamino acids [Palmer, D. " 04/11/2006
- " The assigned physiological functions in the muconate lactonizing enzyme (MLE) subgroup (Lys acid/base catalysts at the ends of the second and sixth beta-strands in the barrel domain) are cycloisomerization (MLE), dehydration (o-succinylbenzoate synthase; OSBS), and epimerization (L-Ala-D/L-Glu epimerase). " 08/01/1993
- " The benzenoid aromatic compound o-succinylbenzoic acid is formed by dehydration of the prearomatic compound 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid by the enzyme o-succinylbenzoate synthase, encoded by the menC gene. " 01/13/2004
- " o-Succinylbenzoate synthase (OSBS) from Amycolatopsis, a member of the enolase superfamily, catalyzes the Mn2+-dependent exergonic dehydration of 2-succinyl-6R-hydroxy-2,4-cyclohexadiene-1R-carboxylate (SHCHC) to 4-(2'-carboxylphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB) in the menaquinone biosynthetic pathway. " 12/16/2003
- " o-Succinylbenzoate synthase (OSBS) from Escherichia coli, a member of the enolase superfamily, catalyzes an exergonic dehydration reaction in the menaquinone biosynthetic pathway in which 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) is converted to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB). "
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2. | Fibrosis (Cirrhosis)
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