o-succinylbenzoic acid synthase

E coli enzyme; with SHCHC synthase catalyzes formation of o-succinylbenzoic acid from isochorismic acid & alpha-ketoglutarate in presence of thiamine pyropyrophosphate; succinic semialdehyde anion is formed by decarboxylation of alpha-ketoglutarate by thiamine pyrophosphate; anion then attacks isochorismic acid, initiating aromatization with elimination of pyruvate & H2O
Also Known As:
2-succinylbenzoic acid synthase; MenC protein, E coli; OSB synthase; o-succinylbenzoate synthase; ortho-succinylbenzoic acid synthase
Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results


1. Gerlt, John A: 4 articles (04/2006 - 12/2003)
2. Taylor Ringia, Erika A: 3 articles (05/2004 - 12/2003)
3. Rayment, Ivan: 3 articles (05/2004 - 12/2003)
4. Garrett, James B: 2 articles (05/2004 - 01/2004)
5. Thoden, James B: 2 articles (05/2004 - 01/2004)
6. Holden, Hazel M: 2 articles (05/2004 - 01/2004)
7. Sakai, Ayano: 1 article (04/2006)
8. Xu, Chengfu: 1 article (04/2006)
9. Xiang, Dao Feng: 1 article (04/2006)
10. Raushel, Frank M: 1 article (04/2006)

Related Diseases

1. Dehydration (Water Stress)
04/11/2006 - "The assigned physiological functions in the muconate lactonizing enzyme (MLE) subgroup (Lys acid/base catalysts at the ends of the second and sixth beta-strands in the barrel domain) are cycloisomerization (MLE), dehydration (o-succinylbenzoate synthase; OSBS), and epimerization (L-Ala-D/L-Glu epimerase). "
05/18/2004 - "This phenomenon has been suggested to occur in the o-succinylbenzoate synthase (OSBS) from a species of Amycolatopsis that catalyzes not only the physiological syn-dehydration reaction of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate but also an accidental racemization of N-acylamino acids [Palmer, D. "
12/25/2001 - "In the muconate lactonizing enzyme (MLE) subgroup of the superfamily, abstraction of a proton adjacent to a carboxylate group initiates reactions, including cycloisomerization (MLE), dehydration [o-succinylbenzoate synthase (OSBS)], and 1,1-proton transfer (catalyzed by an OSBS that also catalyzes a promiscuous N-acylamino acid racemase reaction). "
08/01/1993 - "The benzenoid aromatic compound o-succinylbenzoic acid is formed by dehydration of the prearomatic compound 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid by the enzyme o-succinylbenzoate synthase, encoded by the menC gene. "
01/13/2004 - "o-Succinylbenzoate synthase (OSBS) from Amycolatopsis, a member of the enolase superfamily, catalyzes the Mn2+-dependent exergonic dehydration of 2-succinyl-6R-hydroxy-2,4-cyclohexadiene-1R-carboxylate (SHCHC) to 4-(2'-carboxylphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB) in the menaquinone biosynthetic pathway. "

Related Drugs and Biologics

1. o-succinylbenzoic acid
2. Vitamin K 2 (Vitamin K2)
3. Phosphopyruvate Hydratase (Enolase)
4. 2- succinyl- 6- hydroxycyclohexa- 2,4- diene- 1- carboxylic acid
5. Protons (Proton)
6. Acids