isochorismic acid (isochorismate)

structure given in first source

Also Known As:

isochorismate; 5-((1-carboxyethenyl)oxy)-6-hydroxy-1,3-cyclohexadiene-1-carboxylic acid; iso-chorismic acid; 1,3-Cyclohexadiene-1-carboxylic acid, 5-((1-carboxyethenyl)oxy)-6-hydroxy-, trans-

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        Chorismic Acid
        isochorismic acid: 11
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cyclohexanecarboxylic Acids
      - Chorismic Acid
        isochorismic acid: 11

Experts

1.	Wildermuth, Mary C: 2 articles (01/2018 - 03/2009)
2.	Bie, Zhilong: 1 article (01/2018)
3.	Cao, Haishun: 1 article (01/2018)
4.	Cheng, Fei: 1 article (01/2018)
5.	Fonseca, Alejandro: 1 article (01/2018)
6.	Gagesch, Kelsey R: 1 article (01/2018)
7.	Greenberg, Jean T: 1 article (01/2018)
8.	Herrera-Vásquez, Ariel: 1 article (01/2018)
9.	Holuigue, Loreto: 1 article (01/2018)
10.	Huang, Yuan: 1 article (01/2018)

Related Diseases

1.	Infections 01/01/2018 - "In Arabidopsis (Arabidopsis thaliana), the chloroplast-localized isochorismate pathway is the main source of SA biosynthesis during abiotic stress or pathogen infections. " 03/01/2009 - "To investigate this later phase of the PM interaction and the role played by SA, we performed replicated global expression profiling for wild-type and SA biosynthetic mutant isochorismate synthase1 (ics1) Arabidopsis from 0 to 7 d after infection. " 01/01/2018 - "FON infection increases the accumulation of free and conjugated salicylic acid (SA) in watermelon grown under wheat intercropping systems through isochorismate (ICS) and phenylalanine ammonia-lyase (PAL) pathways. " 01/01/2023 - "Estimation of defense hormone after infection showed that jasmonic acid (JA) level is higher and salicylic acid (SA) level is lower in gi-100 compared to Col-0 WT. Here, we show that the relative transcript expression of CORONATINE INSENSITIVE1 (COI1) and PLANT DEFENSIN1.2 (PDF1.2) as a marker of the JA pathway is significantly higher while ISOCHORISMATE SYNTHASE1 (ICS1) and NON-EXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1), the markers of the SA pathway, are downregulated in the gi-100 mutants compared to Col-0 plants. "
2.	Disease Resistance 08/01/2010 - "We conclude that (1) lesions induced by intracellular oxidative stress originating in the peroxisomes can be genetically reverted; (2) the isochorismate pathway of SA synthesis couples intracellular oxidative stress to cell death and associated disease resistance responses; and (3) camalexin accumulation was strictly dependent on the simultaneous presence of both H(2)O(2) and SA signals."
3.	Virus Diseases (Viral Diseases) 01/01/2017 - "A key enzyme for SA biosynthesis is isochorismate synthase (ICS), which converts chorismate into isochorismate, and for which there are two genes in Arabidopsis thaliana One (AtICS1) has been shown to be required for increased SA biosynthesis in response to pathogens and its expression can be stimulated throughout the leaf by virus infection and exogenous SA. "
4.	Tuberculosis (Tuberculoses) 07/05/2010 - "tuberculosis MbtI using a library of functionalized benzoate-based inhibitors designed to mimic the substrate (chorismate) and intermediate (isochorismate) of the MbtI-catalyzed reaction. "
5.	Neoplasms (Cancer) 05/01/2013 - "The Rubiaceae species, Ophiorrhiza pumila, accumulates camptothecin, an anti-cancer alkaloid with a potent DNA topoisomerase I inhibitory activity, as well as anthraquinones that are derived from the combination of the isochorismate and hemiterpenoid pathways. "

Related Drugs and Biologics

1.	Salicylic Acid (2 Hydroxybenzoic Acid)
2.	isochorismate synthase
3.	Hemiterpenes
4.	Vitamin K 2 (Vitamin K2)
5.	Phenylalanine Ammonia-Lyase
6.	Hormones (Hormone)
7.	Enzymes
8.	Enterobactin
9.	Type I DNA Topoisomerases (Topoisomerase I)
10.	Camptothecin