2,3,5-triiodobenzoic acid (TIBA)

inhibitor of auxin transport; RN given refers to parent cpd

Also Known As:

TIBA; 2,3,5-triiodobenzoic acid, 14C-labeled; 2,3,5-triiodobenzoic acid, ammonia salt; 2,3,5-triiodobenzoic acid, potassium salt; 2,3,5-triiodobenzoic acid, sodium salt; A 20812; A-20812

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Iodobenzoates
        Triiodobenzoic Acids: 2
        2,3,5-triiodobenzoic acid: 18
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Iodobenzoates
        Triiodobenzoic Acids: 2
        2,3,5-triiodobenzoic acid: 18

Experts

1.	Cho, Hyun-Jong: 2 articles (01/2017 - 04/2016)
2.	Kim, Dae-Duk: 2 articles (01/2017 - 04/2016)
3.	Fernandes, Janaína: 1 article (06/2021)
4.	de Abreu, Jéssica Sodré Silva: 1 article (06/2021)
5.	Amollo, Michael O: 1 article (01/2021)
6.	Dayo, Lilyana: 1 article (01/2021)
7.	Kwambai, Titus: 1 article (01/2021)
8.	Milimo, Emmanuel: 1 article (01/2021)
9.	Oguttu, Monica: 1 article (01/2021)
10.	Okeyo, Edward O: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2016 - "Tumor targeting and cancer diagnosis with HA-TIBA nanoassembly were verified in a CT imaging study using the SCC7 tumor-xenografted mouse model. " 06/01/2021 - "These data demonstrate the relationship between the increased cellular oxidative stress and the anti-tumor action of the TIBA." 01/01/2017 - "This resulted in the SOF/TIBA/PLGA MSs group (IA administration, single dosing, 1 mg/kg) showing a smaller tumor size increase and viable tumor portion compared to the TIBA/PLGA MSs group. " 04/01/2016 - "HA and TIBA can be used to produce HA-TIBA nanoassembly that may be a promising theranostic nanosystem for cancers that express the CD44 receptor. " 06/01/2021 - "TIBA's antitumor activity was demonstrated in lung cancer, but the subcellular mechanisms involving its activity in tumor cells are still unknown. "
2.	Infections 11/01/2020 - "Experiences in promoting sustainability of these interventions have been captured in this study as part of the Tackling Infections to Benefit Africa (TIBA) partnership. " 01/01/2023 - "Tackling Infections to Benefit Africa (TIBA) partnership as a case study." 01/01/2023 - "Tackling Infections to Benefit Africa (TIBA) is a global health research and delivery partnership with a focus on strengthening health systems to combat neglected tropical diseases, malaria and emerging pathogens in Africa. "
3.	Decapitation 04/01/1998 - "The sensitivity of the ovaries to GA(3) can be recovered by removing the apical shoot (plant decapitation) and by blocking the transport of indoleacetic acid (IAA) from the apical shoot with 2,3,5-triiodobenzoic acid. " 10/26/2018 - "High-performance liquid chromatography (HPLC) and qRT-PCR results showed that, after decapitation, the NPA- and TIBA-induced lateral buds germinated due to rapidly decreasing auxin levels, caused by upregulation of the dioxygenase for auxin oxidation gene (DAO). "
4.	Wounds and Injuries (Trauma) 07/01/1990 - "Two observations suggest that the auxin within the epidermal cells is transported in a polar manner: (a) the amount of auxin in the epidermal cells is greatly reduced in the presence of TIBA, and (b) auxin accumulates on the apical side of a wound in the epidermis and is absent on the basal side. " 11/08/2016 - "Auxin flow was manipulated by lateral stem wounds or chemically by auxin efflux inhibitors 2,3,5-triiodobenzoic acid (TIBA), 1-N-naphtylphtalamic acid (NPA), or protein synthesis inhibitor cycloheximide (CHX) treatments, which served to interfere with axillary bud competition. "
5.	Malaria 01/01/2021 - "Patients were enrolled on M-TIBA platform, diagnostic test results digitized, and only positive patients were digitally entitled to malaria treatment. " 01/01/2023 - "Tackling Infections to Benefit Africa (TIBA) is a global health research and delivery partnership with a focus on strengthening health systems to combat neglected tropical diseases, malaria and emerging pathogens in Africa. "

Related Drugs and Biologics

1.	Coloring Agents (Dyes)
2.	CY5.5 cyanine dye
3.	2,3,5-triiodobenzoic acid (TIBA)
4.	Indoleacetic Acids (Auxin)
5.	Dioxygenases
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Transferrin (beta 2 Transferrin)
8.	Messenger RNA (mRNA)
9.	Transferrin Receptors (Transferrin Receptor)
10.	Protein Synthesis Inhibitors

Related Therapies and Procedures

1.	Precision Medicine
2.	Blood Pressure Monitors
3.	Osteotomy
4.	Microspheres (Microsphere)