|1.||Aoki, Junken: 13 articles (05/2014 - 07/2002)|
|2.||Tokumura, Akira: 8 articles (05/2014 - 01/2002)|
|3.||Arai, Hiroyuki: 8 articles (02/2008 - 07/2002)|
|4.||Moolenaar, Wouter H: 6 articles (01/2013 - 07/2002)|
|5.||Yatomi, Yutaka: 5 articles (06/2011 - 07/2006)|
|6.||Fukuzawa, Kenji: 5 articles (05/2010 - 01/2002)|
|7.||van Meeteren, Laurens A: 4 articles (01/2013 - 07/2006)|
|8.||Nakamura, Kazuhiro: 4 articles (06/2011 - 11/2007)|
|9.||Ikeda, Hitoshi: 4 articles (06/2011 - 11/2007)|
|10.||Bollen, Mathieu: 4 articles (11/2009 - 03/2003)|
|1.||Prostatic Neoplasms (Prostate Cancer)
01/01/2011 - "Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. "
05/01/2009 - "Autotaxin (ATX) is an approximately 125-kDa transmembrane protein that is considered to be a tumor progression factor based on its lysophospholipase D activity. "
05/01/2009 - "We previously found that LPA is produced extracellularly by plasma lysophospholipase D (lysoPLD) activity of autotaxin, a tumor cell motility-stimulating protein. "
05/01/2008 - "Autotaxin (ATX) is an approximately 125kDa transmembrane protein known as a tumor progression factor based on its lysophospholipase D (lysoPLD) activity. "
04/10/2007 - "Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity."
|3.||Neoplasm Metastasis (Metastasis)
09/01/2008 - "LPA and its analogues also are feedback inhibitors of the enzyme lysophospholipase D (lysoPLD, a.k.a., autotaxin, ATX), a central regulator of invasion and metastasis. "
05/01/2007 - "LPA and its analogues are also feedback inhibitors of the enzyme lysophospholipase D (lysoPLD, also known as autotaxin), a central regulator of invasion and metastasis. "
07/15/2005 - "Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D."
12/15/2010 - "Here, we describe the synthesis of R-3-CCPA and S-3-CCPA along with their pharmacological properties as inhibitors of lysophospholipase D/autotaxin, agonists of the LPA(5) GPCR, and blockers of lung metastasis of B16-F10 melanoma cells in a C57BL/6 mouse model. "
08/08/2008 - "Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D."
02/01/2002 - "These results indicated that increases in the levels of LPAs generated by lysophospholipase D in the blood of hypercholesterolemic rabbits may be relevant to attachment of monocytes to vascular walls, a key phenomenon observed at an early stage of atherosclerosis."
05/23/2002 - "Hence, excess generation of LPA by lysophospholipase D activity in body fluids has been suggested to be relevant to the pathogenesis of cancer and atherosclerosis."
05/26/2010 - "Overproduction of lysophosphatidic acid (LPA) by lysophospholipase D/autotaxin (lysoPLD/ATX) is postulated to be involved in the promotion of cancer and atherosclerosis. "
03/01/2005 - "Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression."
01/01/2014 - "Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. "
12/01/2010 - "The lysophospholipase D enzyme, autotaxin (ATX), has been linked to numerous human diseases including cancer, neurophatic pain, obesity and Alzheimer's disease. "
|1.||lysophosphatidic acid (MOPA)
|4.||Autocrine Motility Factor
|5.||Adenosine Triphosphatases (ATPase)
|8.||tranilast (N 5')
|1.||Heterologous Transplantation (Xenotransplantation)