prinomide

RN given from Toxline; RN not in Chemline 7/87; structure given in first source

Also Known As:

1-methyl-beta-oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile 2-(N,N-bis(2-hydroxyethyl)amino)ethanol (1:1)salt; CGS 10787B; CGS-10787-B

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Agranulocytosis (Granulocytopenia) 02/01/1997 - "Similarly prinomide, an antiinflammatory drug, was associated with a low incidence of agranulocytosis (<0.3%) in clinical trials, even though chronic toxicity studies in rodents and primates showed no evidence of agranulocytosis with either prinomide or its parahydroxy metabolite, CGS 12094. " 02/01/1997 - "Thus during conditions which lead to elevated levels of H2O2 (e.g., active inflammation), CGS 12094 is rapidly metabolized by MPO to reactive intermediates that may be related to prinomide-induced agranulocytosis." 02/01/1997 - "Activation of CGS 12094 (prinomide metabolite) to 1,4-benzoquinone by myeloperoxidase: implications for human idiosyncratic agranulocytosis."
2.	Inflammation (Inflammations) 02/01/1997 - "Thus during conditions which lead to elevated levels of H2O2 (e.g., active inflammation), CGS 12094 is rapidly metabolized by MPO to reactive intermediates that may be related to prinomide-induced agranulocytosis."
3.	Rheumatoid Arthritis 04/01/1989 - "Prinomide (CGS-10787B), a potential disease modifying drug, was evaluated clinically and biochemically in 15 patients with active rheumatoid arthritis. " 04/01/1989 - "A clinical and biochemical assessment of prinomide in patients with rheumatoid arthritis."

1.	CGS 12094
2.	Peroxidase (Myeloperoxidase)
3.	quinone (benzoquinone)