pectolinarin

antihemorrhagic principle from Chinese plant Cirsium japonicum DC.

Also Known As:

7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        pectolinarin: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        pectolinarin: 10

Experts

1.	Adhikari, Achyut: 1 article (03/2021)
2.	Adhikari, Bikash: 1 article (03/2021)
3.	Bhattarai, Bibek Raj: 1 article (03/2021)
4.	Khadayat, Karan: 1 article (03/2021)
5.	Khanal, Santosh: 1 article (03/2021)
6.	Lamichhane, Ganesh: 1 article (03/2021)
7.	Marasini, Bishnu P: 1 article (03/2021)
8.	Parajuli, Niranjan: 1 article (03/2021)
9.	Rayamajhee, Binod: 1 article (03/2021)
10.	Crasta, Inchara: 1 article (01/2021)

Related Diseases

1.	COVID-19 01/01/2021 - "From the docking and molecular dynamics study, it was revealed that the bioactives namely amritoside, apigenin-6-C-glucosyl7-O-glucoside, pectolinarin and astragalin showed better binding affinities with COVID-19 Mpro. " 03/01/2021 - "Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin-gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol etc. isolated from plants could also be potential drug candidates against COVID-19. "
2.	Neoplasms (Cancer) 09/01/2006 - "FLCJ is stronger than Pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone in inhibiting tumors and promoting immune response significantly. " 09/01/2006 - "FLCJ, pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone can inhibit the growth of the implanted tumors S180 and H22 and promote cellular and humoral immune responses. " 01/01/2021 - "Pharmacological activities data analysis signified the health beneficial potential of pectolinarin for their anti-rheumatoid arthritis, analgesic, anti-inflammatory, hepatoprotective, anti-diabetic, anti-tumor, anti-dengue, antiviral, neuroprotective and antidepressant activity. "
3.	Inflammation (Inflammations) 01/01/2019 - "Activation of the PI3K/Akt pathway by 740Y-P impaired the effects of pectolinarin on cell viability, apoptosis, and inflammation in RA-FLSs. " 01/01/2019 - "Pectolinarin inhibits proliferation, induces apoptosis, and suppresses inflammation in rheumatoid arthritis fibroblast-like synoviocytes by inactivating the phosphatidylinositol 3 kinase/protein kinase B pathway." 08/02/2023 - "Additionally, Pectolinarin recovered protein expression from H2O2-altered levels back to close-to-normal SH-SY5Y cell levels for components of the oxidative stress, inflammation, and apoptosis pathways-such as nuclear factor erythroid 2-related factor 2 (Nrf2), kelch-like ECH-associated protein (Keap1), anti-heme oxygenase 1 (HO-1), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), B-cell lympho-ma-2 (Bcl-2) protein, and Bcl-2-associated X protein (Bax). "
4.	Rheumatoid Arthritis 01/01/2019 - "Pectolinarin inhibits proliferation, induces apoptosis, and suppresses inflammation in rheumatoid arthritis fibroblast-like synoviocytes by inactivating the phosphatidylinositol 3 kinase/protein kinase B pathway." 01/01/2021 - "Pharmacological activities data analysis signified the health beneficial potential of pectolinarin for their anti-rheumatoid arthritis, analgesic, anti-inflammatory, hepatoprotective, anti-diabetic, anti-tumor, anti-dengue, antiviral, neuroprotective and antidepressant activity. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 08/02/2023 - "These findings suggest that pectolinarin has the potential to be used as a plant material for functional foods to be applied in the treatment of neurodegenerative diseases, such as Alzheimer's disease, by mitigating oxidative stress-induced damage to neuronal cells."

Related Drugs and Biologics

1.	astragalin
2.	Proteins (Proteins, Gene)
3.	Flavonoids
4.	acacetin
5.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
6.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
7.	Heme Oxygenase-1
8.	Cyclooxygenase 2 (Cyclooxygenase-2)
9.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
10.	bcl-2-Associated X Protein (bcl 2 Associated X Protein)

Related Therapies and Procedures

1.	Traditional Medicine (Folk Remedies)