|1.||Has, C: 2 articles (06/2012 - 08/2000)|
|2.||Bruckner-Tuderman, L: 2 articles (06/2012 - 08/2000)|
|3.||Le Breton, Frédérique: 1 article (07/2015)|
|4.||Hall, Christine M: 1 article (07/2015)|
|5.||Parenti, Giancarlo: 1 article (07/2015)|
|6.||Offiah, Amaka C: 1 article (07/2015)|
|7.||Andria, Generoso: 1 article (07/2015)|
|8.||Edery, Patrick: 1 article (07/2015)|
|9.||Collardeau-Frachon, Sophie: 1 article (07/2015)|
|10.||Cordier, Marie Pierre: 1 article (07/2015)|
03/01/1991 - "Protection of hippocampal CA1 neurons has been demonstrated with pre-ischemic administration of (S)-emopamil in global ischemia models. "
01/01/1989 - "In the histological series (S)-emopamil was applied at doses of 2, 4 or 6 mg/kg before the induction of ischemia. "
08/01/1987 - "The brains were perfused with a fluorocarbon emulsion for 30 min, and after 30 min of ischemia, perfusion was reinstituted for 5, 30, or 60 min. Global cerebral perfusion rate was increased by emopamil throughout the perfusion period and, accordingly, in brains perfused at a constant flow rate, perfusion pressure was reduced by the drug. "
03/01/1989 - "In the cerebral blood flow studies intravenous infusion of 0.1 mg/(kg min) (S)-emopamil was begun 5 min after the end of ischemia. "
03/01/1991 - "Our laboratory has compared the efficacy of pre- vs. post-ischemic (S)-emopamil treatment on neuronal necrosis resulting from 10 min of transient normothermic global ischemia in the rat. "
|2.||Brain Ischemia (Cerebral Ischemia)
12/01/1990 - "Thus, pretreatment with (S)-emopamil is beneficial in decreasing the severity of neuronal injury in global brain ischemia."
06/01/1995 - "These results indicate that postischemic treatment with levemopamil at this dose, and in this model of focal cerebral ischemia and reperfusion, does not attenuate the ischemic damage."
02/01/1993 - "The phenylalkylamine emopamil prevents brain damage due to experimental cerebral ischemia. "
12/01/1990 - "We investigated the effect of (S)-emopamil on the histopathologic consequences of global brain ischemia in anesthetized rats. "
03/01/1991 - "In focal cerebral ischemia (middle cerebral artery occlusion in the rat), our laboratory has demonstrated a marked reduction in cortical infarct volume with (S)-emopamil pre- or post-treatment.(ABSTRACT TRUNCATED AT 250 WORDS)"
|3.||Brain Injuries (Brain Injury)
03/01/1991 - "Postischemic (S)-emopamil therapy ameliorates focal ischemic brain injury in rats."
02/01/1994 - "Animals were subjected to fluid percussion brain injury of moderate severity (2.1 atm), and received (S)-emopamil (20 mg/kg, i.p., n = 10) or saline (n = 10) at 20 minutes postinjury and 2.5 hours after the first injection of the drug. "
02/01/1994 - "(S)-emopamil attenuates acute reduction in regional cerebral blood flow following experimental brain injury."
10/01/1992 - "In addition, (S)-emopamil also attenuated the deficits in motor function that were observed over a 2-week period following brain injury. "
10/01/1992 - "Profound memory dysfunction induced by brain injury was significantly attenuated following (S)-emopamil treatment. "
|3.||Calcium Channels (Calcium Channel)
|4.||Serotonin (5 Hydroxytryptamine)
|5.||Dizocilpine Maleate (Dizocilpine)
|6.||Carrier Proteins (Binding Protein)