|1.||Hsieh, Ching-Liang: 4 articles (05/2014 - 01/2009)|
|2.||Tang, Nou-Ying: 3 articles (05/2014 - 01/2009)|
|3.||Ho, Tin-Yun: 2 articles (05/2014 - 01/2009)|
|4.||Liu, Chung-Hsiang: 2 articles (01/2013 - 01/2009)|
|5.||Zhu, Zhi-Ru: 1 article (11/2015)|
|6.||Shao, Hui: 1 article (11/2015)|
|7.||Mi, Ze: 1 article (11/2015)|
|8.||Ren, Shuan-Cheng: 1 article (11/2015)|
|9.||Zhang, Cheng-Huan: 1 article (11/2015)|
|10.||Ji, Wei-Gang: 1 article (11/2015)|
09/01/2014 - "Isorhynchophylline is one of the major alkaloids from the Uncaria hook possessing the effects of lowered blood pressure, vasodilatation and protection against ischemia-induced neuronal damage. "
12/03/2004 - "Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action."
12/03/2004 - "In this study we examined the protective effects of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus and interaction of these alkaloids with neurotransmitter receptors in a receptor expression model of Xenopus oocytes. "
12/03/2004 - "Together with our previous findings that rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia."
12/03/2004 - "Rhynchophylline and isorhynchophylline, as well as the N-methyl-D-aspartate (NMDA) antagonist (+/-)-2-amino-5-phosphono-valeric acid (APV), the muscarinic M1 receptor antagonist pirenzepine, and the 5-HT2 receptor antagonist ketanserin, attenuated the in vitro ischemia-induced neuronal damage in a concentration-dependent manner. "
09/01/2011 - "As one important constituent extracted from a traditional Chinese medicine, Uncaria Rhynchophylla Miq Jacks, isorhynchophylline has been used to treat hypertension, epilepsy, headache, and other illnesses. "
05/15/2014 - "Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor."
10/28/2010 - "Rhynchophylline mainly acts on cardiovascular and central nervous system diseases, including hypertension, bradycardia, arrhythmia, sedation, vascular dementia, epileptic seizures, drug addiction, and cerebral ischemia. "
01/01/2009 - "We hypothesized that UR and its major component rhynchophylline (RH), reduce epileptic seizures in rats treated with kainic acid (KA) by inhibiting nuclear factor-kappaB (NF-kappaB) and activator-protein-1 (AP-1) activity, and by eliminating superoxide anions. "
|3.||Cardiac Arrhythmias (Arrythmia)
09/01/2011 - "Protective effects of isorhynchophylline on cardiac arrhythmias in rats and guinea pigs."
09/01/2011 - "Whether isorhynchophylline protects hearts against cardiac arrhythmias is still incompletely investigated. "
09/01/2011 - "In summary, isorhynchophylline played a remarkably preventive role in cardiac arrhythmias through the inhibition of calcium currents in rats and guinea pigs."
09/01/2011 - "Additionally, the onset time of cardiac arrhythmias induced by calcium chloride was prolonged, and the duration was shortened in rats pretreated with isorhynchophylline. "
09/01/2011 - "The dose of ouabain required to induce cardiac arrhythmias was much larger in guinea pigs administered with isorhynchophylline. "
|4.||Central Nervous System Diseases (CNS Diseases)
10/28/2010 - "This review examined the pharmacological studies and mechanisms of rhynchophylline, with an emphasis on cardiovascular and central nervous system diseases linked to the ethnopharmacological uses of Uncaria species. "
06/01/2012 - "Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases."
10/28/2010 - "As a candidate drug for several cardiovascular and central nervous system diseases, rhynchophylline will attract scientists to pursue the potential pharmacological effects and mechanisms with new technologies. "
01/01/2014 - "Rhynchophylline (Rhy) is the major component of Uncaria species, which is used in Chinese traditional medicine for the treatment of central nervous system disorders. "
10/28/2010 - "Rhynchophylline treatment of cardiovascular and central nervous system diseases has a strong linkage with traditional concepts and uses of Uncaria species in ethnopharmacological medicine, such as treatment for lightheadedness, convulsions, numbness, and hypertension. "
|3.||Neurotransmitter Receptors (Neurotransmitter Receptor)
|4.||Kainic Acid (Kainate)
|5.||Brain-Derived Neurotrophic Factor (BDNF)
|7.||Ionotropic Glutamate Receptors
|8.||JNK Mitogen-Activated Protein Kinases
|9.||Muscarinic M1 Receptor
|10.||NF-kappa B (NF-kB)
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)