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N(12)-diethylspermine N(1)

structure in first source

Also Known As:

N(1), N(12)-diethylspermine; 1,12-BESm; Be-3-4-3; N(1),N(12)-bis(ethyl)spermine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Spermine: 1076
      - N(12)-diethylspermine N(1): 2
  - Biogenic Amines: 992
    - Biogenic Polyamines: 11
      - Putrescine: 919
        Spermidine: 1153
        Spermine: 1076
        N(12)-diethylspermine N(1): 2

Experts

1.	Astancolle, Serenella: 1 article (01/2004)
2.	Bettuzzi, Saverio: 1 article (01/2004)
3.	Caporali, Andrea: 1 article (01/2004)
4.	Marverti, Gaetano: 1 article (01/2004)
5.	Monti, Maria Giuseppina: 1 article (01/2004)
6.	Moruzzi, Maria Stella: 1 article (01/2004)
7.	Gelinas, C: 1 article (03/2001)
8.	Klinge, C M: 1 article (03/2001)
9.	Lewis, J S: 1 article (03/2001)
10.	Shah, N: 1 article (03/2001)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/2004 - "Cisplatin (DDP)-resistance confers a deficient expression of spermidine/spermine N(1)-acetyltransferase (SSAT) gene in response to the spermine analog N(1),N(12)-bis(ethyl)spermine (BESpm) in the DDP-resistant human ovarian carcinoma cell line (C13*), compared with their parental DDP-sensitive 2008 cells. "
2.	Breast Neoplasms (Breast Cancer) 03/29/2001 - "Our results with BE-3-4-3 and BE-3-3-3 suggest that down-regulation of ER alpha- and NF-kappa B-regulated genes is a possible mechanism for the action of polyamine analogs in inducing apoptosis of breast cancer cells."

Related Drugs and Biologics

1.	N(1),N(11)-diethylnorspermine
2.	NF-kappa B (NF-kB)
3.	Spermine
4.	Polyamines
5.	Cisplatin (Platino)
6.	diamine N-acetyltransferase (spermidine acetyltransferase)