|1.||Hoffman, Stephen L: 12 articles (12/2015 - 01/2013)|
|2.||Billingsley, Peter F: 7 articles (12/2015 - 01/2014)|
|3.||Hill, Adrian V S: 7 articles (04/2015 - 06/2012)|
|4.||Sim, B Kim Lee: 6 articles (12/2015 - 01/2013)|
|5.||Sauerwein, Robert W: 6 articles (05/2015 - 08/2012)|
|6.||Hodgson, Susanne H: 6 articles (04/2015 - 01/2014)|
|7.||Gunasekera, Anusha: 6 articles (01/2015 - 01/2013)|
|8.||James, Eric R: 5 articles (05/2015 - 01/2014)|
|9.||Draper, Simon J: 5 articles (01/2015 - 01/2014)|
|10.||Hermsen, Cornelus C: 4 articles (05/2015 - 04/2014)|
05/01/2015 - "falciparum lysate serology can be used to identify individuals with better parasite control but weaker IFN-γ responses in circulating lymphocytes, which may help to stratify volunteers in future CHMI trials in areas where malaria is endemic. "
06/15/2014 - "Since 1986, investigators at Walter Reed Army Institute of Research (WRAIR) have been using controlled human malaria challenge (CHMI) in malaria-naive adults in order to define the protective efficacy of a malaria vaccine and thus guide programmatic decisions on vaccine candidates. "
01/01/2013 - "Microscopy is the gold standard used for the diagnosis of Pf malaria after CHMI, but qPCR identifies parasites earlier. "
01/01/2015 - "falciparum blood-stage malaria cell banks represents a suitable approach for the generation of material suitable for CHMI studies. "
01/01/2015 - "Three different strategies are described for the manufacture of clinical grade cultured malaria cell banks suitable for use in CHMI studies. "
01/01/2015 - "Infection rate and pre-patent period depended on dose, and injection of 3,200 PfSPZ led to a GMPPP similar to CHMI with five PfSPZ-infected mosquitoes. "
12/09/2015 - "The group that received 5 × 10(4) PfSPZ total dose in eight 10 μL injections had a 100% infection rate and the shortest prepatent period (mean of 12.7 days), approaching the prepatent period for the current CHMI standard of five infected mosquitoes. "
04/01/2015 - "We conducted an open-label, 2-site, partially randomized Plasmodium falciparum sporozoite controlled human malaria infection (CHMI) study to compare the clinical efficacy of ChAd63-MVA CS with ChAd63-MVA ME-TRAP. "
01/01/2014 - "The use of quantitative real-time PCR (qPCR) has allowed for precise quantification of parasites in the prepatent period and greatly improved the reproducibility and statistical power of controlled human malaria infection (CHMI) trials. "
10/01/2013 - "falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1) (NMRC-M3V-D/Ad-PfCA Vaccine) induced 27% protection against controlled human malaria infection (CHMI). "
|3.||Bites and Stings (Sting)
12/09/2015 - "Until recently CHMI was only carried out by the bite of infected mosquitoes. "
01/01/2015 - "So far, CHMI is done by exposure of volunteers to bites of five mosquitoes carrying Plasmodium falciparum sporozoites (PfSPZ), a technique available in only a few centres worldwide. "
10/01/2013 - "falciparum CHMI administered by mosquito bite. "
01/01/2013 - "We reported that CHMI using the bites of 3 PfSPZ-infected mosquitoes reared aseptically in compliance with current good manufacturing practices (cGMP) was successful in 6 participants. "
01/01/2013 - "Exposure to the bites of 3 aseptically-raised, PfSPZ-infected mosquitoes is a safe, effective procedure for CHMI in malaria-naïve adults. "
|5.||Falciparum Malaria (Plasmodium falciparum Malaria)
|4.||Indicators and Reagents (Reagents)
|5.||Antimalarials (Antimalarial Agents)
|6.||N-acetyltalosaminuronic acid (NAT)
|8.||A-Form DNA (A-DNA)
|9.||Merozoite Surface Protein 1 (MSA1)