pobilukast

a leukotriene receptor antagonist; an antiasthmatic agent; structure in first source; RN refers to (R-(R*,S*)-isomer

Also Known As:

2-hydroxy-3-((2-carboxyethyl)thio)-3-(2-(8-phenyloctyl)phenyl)propanoic acid; SK&F 104353; SK&F 104353-Z2; SK&F-104353; SKF 104353; pobilukast edamine; pobilukast edamine, (R-(R*,S*))-isomer; pobilukast, sodium salt

Networked: 9 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - pobilukast: 9

Experts

1.	Aggarwal, Varinder K: 1 article (08/2002)
2.	Hynd, George: 1 article (08/2002)
3.	Picoul, Willy: 1 article (08/2002)
4.	Vasse, Jean-Luc: 1 article (08/2002)

Related Diseases

1.	Shock 06/20/1989 - "These data indicate that the peptidoleukotriene receptor antagonist, SK&F 104353 is beneficial in splanchnic artery occlusion shock, and furthermore suggests that it may be a therapeutically useful agent in bowel ischemic shock." 06/20/1989 - "Therefore, the survival rate of the splanchnic artery occlusion shock group of rats receiving SK&F 104353 was improved to 100% compared with 50% survival for the vehicle-treated splanchnic artery occlusion shock group (P less than 0.025). " 06/20/1989 - "The purpose of this study was to examine the effects of a new potent peptidoleukotriene receptor antagonist, SK&F 104353, in splanchnic artery occlusion shock. " 06/20/1989 - "Anesthetized rats subjected to splanchnic artery occlusion shock survived an average of only 98 +/- 8 min whereas all animals receiving SK&F 104353 survived the 2 h reperfusion period (P less than 0.02 from vehicle). " 06/20/1989 - "In the splanchnic artery occlusion shock + SK&F 104353 group the increase in the plasma activities of the lysosomal hydrolase, cathepsin D, and the cardiotoxic peptide, myocardial depressant factor, were significantly attenuated in comparison to the splanchnic artery occlusion shock + vehicle group (P less than 0.025). "
2.	Myocardial Reperfusion Injury 05/01/1989 - "This study was designed to assess the effect of a peptidoleukotriene receptor antagonist, SK&F 104353, for limiting myocardial damage and neutrophil accumulation in rats subjected to myocardial reperfusion injury (MI/R). "
3.	Asthma (Bronchial Asthma) 08/01/1991 - "The effect of prior inhalation of the sulfidopeptide leukotriene receptor antagonist, SK&F 104353 (963 +/- 43.7 micrograms; mean +/- SEM), on (LTC4)- and leukotriene E4 (LTE4)-induced bronchoconstriction has been studied in six subjects with asthma (six male subjects, aged 24 to 36 years). " 08/01/1991 - "The effect of inhalation of the leukotriene receptor antagonist, SK&F 104353, on leukotriene C4- and leukotriene E4-induced bronchoconstriction in subjects with asthma." 08/28/2002 - "It was found that epoxyamides could be converted into epoxyketones by reaction with organolithium reagents and that they could be ring-opened by nucleophiles with complete regioselectivity using Yb(OTf)3. The practicality of the process has been exemplified in the synthesis of SK&F 104353, a leukotriene D4 antagonist in the potential treatment of bronchial asthma." 05/01/1990 - "We compared the effects of pretreatment of 800 micrograms of inhaled Smith Kline & French (SK&F) 104353, a leukotriene receptor antagonist, and 120 mg of oral terfenadine on the bronchial responses to inhaled histamine in 12 subjects with asthma. " 05/01/1990 - "Effects of SK&F 104353, a leukotriene receptor antagonist, on the bronchial responses to histamine in subjects with asthma: a comparative study with terfenadine."
4.	Aspirin-Induced Asthma 10/01/1991 - "The potent and selective sulfidopeptide leukotriene antagonist, SK&F 104353, inhibits aspirin-induced asthma."
5.	Endotoxemia 05/01/1988 - "These data indicate clearly the pathophysiologic role of peptidoleukotrienes in endotoxemia and suggest SK&F 104353 could be useful for ameliorating some of the deleterious sequelae associated with this condition." 05/01/1988 - "Beneficial effects of the peptidoleukotriene receptor antagonist, SK&F 104353, on the responses to experimental endotoxemia in the conscious rat."

Related Drugs and Biologics

1.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)
2.	Leukotriene E4
3.	Leukotriene D4
4.	Leukotriene C4
5.	Terfenadine (Seldane)
6.	Leukotrienes
7.	Pyrilamine (Mepyramine)
8.	Peptides (Polypeptides)
9.	Myocardial Depressant Factor
10.	Indicators and Reagents (Reagents)

Related Therapies and Procedures

1.	Intradermal Injections