glucopiericidin A

from Streptomyces pactum S48727 as co-metabolite of piericidin A(1); structure given in first source; glycoside antibiotic

Also Known As:

piericidin A(1)-10-O-beta-D-glucoside; beta-D-Glucopyranoside, 10-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridinyl)-2,4,8-trimethyl-1-(1-methyl-1-propenyl)-3,5,8-decatrienyl, (R-(R*,R*-(all-E)))-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - glucopiericidin A: 4

Experts

1.	Chen, Yulian: 2 articles (01/2021 - 01/2019)
2.	Li, Kunlong: 2 articles (01/2021 - 01/2019)
3.	Liang, Zhi: 2 articles (01/2021 - 01/2019)
4.	Liu, Yonghong: 2 articles (01/2021 - 01/2019)
5.	Tang, Lan: 2 articles (01/2021 - 01/2019)
6.	Zhan, Zhikun: 2 articles (01/2021 - 01/2019)
7.	Zhou, Xuefeng: 2 articles (01/2021 - 01/2019)
8.	Imoto, Masaya: 2 articles (09/2018 - 08/2015)
9.	Dai, Fahong: 1 article (01/2021)
10.	Gu, Tanwei: 1 article (01/2021)

Related Diseases

1.	Carcinoma (Carcinomatosis) 08/01/2015 - "Here we introduce our recent study that metabolomics was applied to identify the molecular target of glucopiericidin A, which was isolated through a screening of natural products for an inhibitor of cellular filopodia protrusion in carcinoma cells." 01/01/2021 - "Reported as two antirenal cell carcinoma (RCC) drug candidates, marine-derived compounds piericidin A (PA) and glucopiericidin A (GPA) exhibit hepatotoxicity in renal carcinoma xenograft mice. "
2.	Prostatic Neoplasms (Prostate Cancer) 09/24/2018 - "EGF: Epidermal growth factor; PDGF: Platelet-derived growth factor; CRPC: Castration-resistant prostate cancer; AR: Androgen receptor; FTase: Farnesyl transferase; 5-LOX: 5-Lipoxygenase; LT: Leukotriene; CysLT1: Cysteinyl leukotriene receptor 1; GPA: Glucopiericidin A; PA: Piericidin A; XN: Xanthohumol; VCP: Valosin-containing protein; ACACA: Acetyl-CoA carboxylase-α."
3.	Neoplasms (Cancer) 01/01/2019 - "By exploring the mechanisms of two representative natural piericidin compounds, piericidin A (PA) and glucopiericidin A (GPA), peroxiredoxin 1 (PRDX1) is detected as a potential target by transcriptome data of PA-treated ACHN cells, as well as the paired RCC tumor versus adjacent nontumor tissues. "
4.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/2021 - "Reported as two antirenal cell carcinoma (RCC) drug candidates, marine-derived compounds piericidin A (PA) and glucopiericidin A (GPA) exhibit hepatotoxicity in renal carcinoma xenograft mice. "

Related Drugs and Biologics

1.	piericidin A
2.	Peroxiredoxins
3.	Leukotrienes
4.	Transferases
5.	Androgen Receptors (Androgen Receptor)
6.	Platelet-Derived Growth Factor
7.	Epidermal Growth Factor (EGF)
8.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
9.	Acetyl-CoA Carboxylase
10.	Valosin Containing Protein

Related Therapies and Procedures

1.	Castration