hyoscyamine (6S)-dioxygenase

a 2-oxoglutarate-dependent dioxygenase that catalyzes hydroxylation of L-hyoscyamine to 6beta-hydroxyhyoscyamine in biosynthetic pathway to scopolamine; requires Fe2+

Also Known As:

D4H enzyme; desacetylvindoline 4-hydroxylase; hyoscyamine 6 beta-hydroxylase; hyoscyamine 6beta-hydroxylase

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        hyoscyamine (6S)-dioxygenase: 2

Experts

1.	Medina, Braulio: 1 article (08/2006)
2.	Ravelo, Angel G: 1 article (08/2006)
3.	Zárate, Rafael: 1 article (08/2006)
4.	el Jaber-Vazdekis, Nabil: 1 article (08/2006)

Related Diseases

1.	Infections 08/01/2006 - "Atropa baetica hairy roots, over-expressing cDNA from Hyoscyamus niger encoding the gene for hyoscyamine 6beta-hydroxylase (H6H), were produced by Agrobacterium rhizogenes infection. "
2.	Dehydration (Water Stress) 05/01/1987 - "To determine whether a dehydration step is involved in scopolamine biosynthesis, [6-(18)O]6beta-hydroxyhyoscyamine was prepared from l-hyoscyamine and (18)O(2) using hyoscyamine 6beta-hydroxylase obtained from root cultures of Hyoscyamus niger L. "

Related Drugs and Biologics

1.	Hyoscyamine
2.	Complementary DNA (cDNA)
3.	Scopolamine (Hyoscine)