aurachin D

extracted from myxobacterium, Stigmatella aurantiaca strain Sg a15; MF: C25-H33-N-O; MW: 363; structure given in first source

Also Known As:

aurachin-D; 4(1H)-Quinolinone, 2-methyl-3-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

1.	Malaria 01/20/2023 - "The natural product aurachin D is a farnesylated quinolone alkaloid, which is known to possess activity against the causative agent of malaria, Plasmodium spp. In this study, we show that aurachin D inhibits other parasitic protozoa as well. "
2.	Communicable Diseases (Infectious Diseases) 06/17/2023 - "Aurachin D is a selective inhibitor of the cytochrome bd oxidase, which has received increasing attention as a target for the treatment of infectious diseases caused by mycobacteria. " 11/03/2022 - "Aurachin D is a potent inhibitor of cytochrome bd oxidases, which are potential targets in the treatment of infectious diseases. "
3.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2013 - "The loss of mitochondrial membrane potential induced by aurachins in human U-2 OS osteosarcoma cells was studied, showing the best activity for aurachin D and a naphthalene analogue, yet without totally explaining the observed cytotoxic activity of the compounds. "
4.	Visceral Leishmaniasis (Kala Azar) 01/20/2023 - "Obviously, the naturally occurring aurachin D features already a privileged structure, especially for the inhibition of the causative agent of visceral leishmaniasis."
5.	Leishmaniasis 06/17/2023 - "Moreover, aurachin D possesses remarkable activities against Leishmania donovani, the causative agent of leishmaniasis. "

1.	Quinolones
2.	Alkaloids
3.	Oxidoreductases (Dehydrogenase)
4.	Cytochromes
5.	naphthalene