|1.||Ohmori, K: 2 articles (04/2000 - 01/2000)|
|2.||Aikawa, N: 2 articles (04/2000 - 01/2000)|
|3.||Kobayashi, H: 2 articles (04/2000 - 01/2000)|
|4.||Horikoshi, K: 1 article (04/2000)|
|5.||Maeda, H: 1 article (04/2000)|
01/01/1991 - "Here we show that CGS 9343B, like other calmodulin antagonists reported previously, is most effective in treatment of burns. "
01/01/1991 - "3. As CGS 9343B is a more selective probe for calmodulin function than other inhibitors, the similarity of its effects on burns to that of other calmodulin antagonists, strongly suggest that their action on burns is mediated through calmodulin inhibition."
01/01/1991 - "Effect of the calmodulin antagonist CGS 9343B on skin burns."
01/01/1991 - "2. The effectiveness of CGS 9343B on skin burns was evaluated by electron microscopic studies, as well as by measurements of hemoglobin, ATP and enzymes which are markedly changed in the burned skin. "
04/01/1996 - "DuPont and colleagues showed, for example, that oral therapy with zaldaride maleate relieves symptoms of disease and shortens the duration of diarrhea in travelers with ETEC-induced diarrhea. "
10/01/1989 - "CGS 9343B was the most potent of these agents, eliminating diarrhea in 100% of mice at a dose of 1 mg/kg (p.o.). "
04/01/2000 - "Zaldaride maleate (ZAL), a calmodulin inhibitor, that ameliorates secretory diarrhea in rodents, has a racemic structure. "
01/01/2000 - "The amelioration of secretory diarrhea has been reported after the administration of zaldaride maleate (ZAL), a selective calmodulin inhibitor, to male rodents. "
02/01/1998 - "Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats."
06/05/1992 - "The calmodulin inhibitor 1,3-dihydro-1-[1-((4-methyl-4H,6H-pyrrolo[1,2-a]-[4,1]benzoxazepin - 4-yl)methyl)-4-piperidinyl]-2H-benzimidazol-2-one maleate (CGS 9343B) caused a reversible block of voltage-activated Ca2+, Na+, and K+ currents in differentiated rat pheochromocytoma (PC12) cells. "
12/01/1999 - "Effect of zaldaride maleate, an antidiarrheal compound, on visceral pain reflex induced by small intestinal distention in anesthetized rats."
12/01/1999 - "Using distention of the small intestine as a visceral pain model, we investigated the effect of zaldaride maleate (ZAL), a selective inhibitor of calmodulin, on the depressor response. "
10/17/1996 - "We investigated here the effect of four different calmodulin antagonists: thioridazine (10-[2-(1-methyl-2-piperidyl) ethyl]-2-methylthiophenothiazine), CGS 9343B (1,3-dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a] [4,1]-benzoxazepin-4-yl)methyl]-4-piperidinyl]-2 H-benzimidazol-2-one (1:1) maleate), clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate, the two stimulatory signal molecules of glycolysis, and on ATP content and cell viability in B16 melanoma cells. "
|1.||Calmodulin (Calcium-Dependent Activator Protein)
|2.||Adenosine Triphosphate (ATP)
|5.||maleic acid (maleate)
|6.||3-O-Methylglucose (3 O Methylglucose)
|7.||1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)
|10.||Morphine (MS Contin)