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SIPI 549

RN refers to HCl; structure given in first source

Also Known As:

4'-methyl-7-(2-hydroxy-3-isopropylaminopropoxy)flavone; SIPI-549; methylflavonolamine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        SIPI 549: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        SIPI 549: 5

Related Diseases

1.	Atherosclerosis 03/01/1993 - "Methylflavonolamine protects aorta from atherosclerosis in cholesterol-fed rabbits." 03/01/1993 - "The effect of methylflavonolamine [4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)-flavone hydrochloride, MFA], synthesized recently by the Shanghai Institute of Pharmaceutical Industry, on the development of atherosclerosis was studied in male New Zealand white rabbits fed cholesterol for 10 wk. MFA, 7 mg.kg-1 daily ip, did not significantly alter the serum total cholesterol, HDL, and triglyceride levels, but significantly lowered the aortic cholesterol and calcium contents. "
2.	Reperfusion Injury 07/01/1995 - "To examine the possible beneficial action of methylflavonolamine (MFA) on cerebral ischemia/reperfusion injury. " 07/01/1995 - "Protection of methylflavonolamine against acute cerebral ischemia reperfusion injury in rats."
3.	Myocardial Infarction 05/01/1993 - "Effects of methylflavonolamine (MFA) on TXA2 and PGI2 plasma levels in rabbits of myocardial infarction were investigated. " 05/01/1993 - "[Effects of methylflavonolamine on TXA2 and PGI2 plasma levels in rabbits with myocardial infarction]."
4.	Hypotension (Low Blood Pressure) 07/01/1989 - "When SIPI-549 was administered intravenously to the intact donor dog, a slight hypotension was induced in a dose range of 0.01 to 3 mumol/kg. At the same time, slight negative chronotropic and inotropic responses appeared in isolated and perfused atria, suggesting a cardiac depressant action. "
5.	Brain Ischemia (Cerebral Ischemia) 07/01/1995 - "To examine the possible beneficial action of methylflavonolamine (MFA) on cerebral ischemia/reperfusion injury. " 07/01/1995 - "Protection of methylflavonolamine against acute cerebral ischemia reperfusion injury in rats."

Related Drugs and Biologics

1.	Triglycerides (Triacylglycerol)
2.	HDL Cholesterol
3.	Cholesterol
4.	Calcium
5.	Anti-Arrhythmia Agents
6.	flavone