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bryodin
MW 30,000; ribosome-inactivating glycoprotein from roots of Bryonia dioica L. (white bryony); also found in barley seeds; amino acid sequence has been determined
Also Known As:
bryodin 1; bryodin 1 protein, Bryonia dioica; bryodin 2; bryodin 2 protein, Bryonia dioica; bryodin protein, Bryonia dioica
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Glycoside Hydrolases: 871
N-Glycosyl Hydrolases: 36
Ribosome Inactivating Proteins: 51
Type 1 Ribosome Inactivating Proteins: 3
bryodin: 3
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Plant Proteins: 334
Ribosome Inactivating Proteins: 51
Type 1 Ribosome Inactivating Proteins: 3
bryodin: 3
Related Diseases
1.
Neoplasms (Cancer)
12/15/1986 - "
From all its properties, bryodin can be considered to be a ribosome-inactivating protein, similar to those already known [reviews: Barbieri & Stirpe (1982) Cancer Surveys 1, 489-520; Stirpe & Barbieri (1986) FEBS Lett.
"
2.
Lymphoma (Lymphomas)
01/01/1993 - "
Bryodin, a single-chain ribosome-inactivating protein (RIP) isolated from Bryonia cretica ssp dioica (cucurbitaceae), was found to selectively inhibit the growth of persistently HIV-1-infected T lymphoma cells (KE37/1) and human lung fibroblast when used in concentrations from 2-20 micrograms/ml. Uninfected KE37/1 cells remained unaffected at the same doses of bryodin.
"
3.
Choriocarcinoma
07/01/1992 - "
The effect of several ribosome-inactivating proteins (saporin 6, dianthin 32, pokeweed antiviral protein from seeds, gelonin, bryodin-R, and momordin) on primary cultures of human trophoblasts and human embryonal fibroblasts and on choriocarcinoma (JAR and BeWo) and ovarian carcinoma (TG) cell lines was studied.
"
4.
Carcinoma (Carcinomatosis)
07/01/1992 - "
The effect of several ribosome-inactivating proteins (saporin 6, dianthin 32, pokeweed antiviral protein from seeds, gelonin, bryodin-R, and momordin) on primary cultures of human trophoblasts and human embryonal fibroblasts and on choriocarcinoma (JAR and BeWo) and ovarian carcinoma (TG) cell lines was studied.
"
Related Drugs and Biologics
1.
Saporins
2.
Ribosome Inactivating Proteins
3.
momordin
4.
Gelonium multiflorum GEL protein
5.
pokeweed antiviral protein