ZIMET 54-79

RN given refers to cpd without isomeric designation; structure given in first source

Also Known As:

3,4-dimethoxy-10,11-dimethyl-6,6a,7,8,13,13a-hexahydro-(1)-benzopyrano-(4,3-b)-1,5-benzodiazepine; ZIMET 54-79, (6aR-(cis))-isomer; ZIMET 54-79, (6aS-(cis))-isomer; ZIMET 54-79, cis-(+-)-isomer; ZIMET 54-79, trans-(+-)-isomer; ZIMET 5479; Zimet 55-79

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        ZIMET 54-79: 2

Related Diseases

1.	Experimental Melanoma 01/01/1987 - "It was found, that (+)cis-3,4-dimethoxy-10,11-dimethyl-6,6aR,7,8,13, 13aS-hexahydro-[I]-benzopyrano-[4,3-b]-1,5-benzodiazepine (ZIMET 54/79) increased the life span (ILS) of C57BL/6/Jena mice suffering from transplanted B16 melanoma (ip.) by 57% (9 times ip. "
2.	Melanoma (Melanoma, Malignant) 01/01/1987 - "Finally ZIMET 54/79 tested on AMel 3 hamster melanoma (strain Z3) decreased the mean tumour volume by 72% (125 mg/kg)."
3.	Leukemia L1210 04/01/1990 - "Cell membrane bound adenylate cyclase is stimulated by ZIMET 54/79, resulting in an increase of 103% in the level of cAMP in mouse L1210 leukemia cells. "

Related Drugs and Biologics

1.	Benzodiazepines
2.	Adenylyl Cyclases (Adenylyl Cyclase)