|1.||Zhang, Ruifeng: 4 articles (08/2014 - 10/2009)|
|2.||Cai, Jiangxia: 3 articles (01/2015 - 06/2014)|
|3.||Xing, Jianfeng: 3 articles (01/2015 - 06/2014)|
|4.||Chen, Siying: 3 articles (01/2015 - 06/2014)|
|5.||Zhang, Weipeng: 3 articles (01/2015 - 06/2014)|
|6.||Dong, Yalin: 3 articles (01/2015 - 06/2014)|
|7.||Zhou, Lin: 3 articles (03/2014 - 10/2009)|
|8.||Zheng, Xiaowei: 2 articles (01/2015 - 10/2014)|
|9.||Lu, Jun: 2 articles (10/2014 - 06/2014)|
|10.||Hu, Sasa: 2 articles (10/2014 - 06/2014)|
|1.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer."
10/15/2014 - "These results not only provide insight into the potential application of SAA in reversing paclitaxel resistance, thus facilitating the sensitivity of breast cancer chemotherapy, but also highlight a potential role of transgelin 2 in the development of paclitaxel resistance in breast cancer. "
01/01/2015 - "This study investigated the potential of transgelin 2 and salvianolic acid A to modulate the resistance and the migration and invasion abilities of paclitaxel-resistant human breast cancer cells (MCF-7/PTX). "
10/15/2014 - "The purpose of this study was to investigate the role of transgelin 2 in human breast cancer paclitaxel resistance cell line (MCF-7/PTX) and the reversal mechanism of salvianolic acid A (SAA), a phenolic active compound extracted from Salvia miltiorrhiza. "
01/01/2015 - "These findings indicate that salvianolic acid A can reverse the paclitaxel resistance and inhibit the migration and invasion abilities of human breast cancer cells by down-regulating the expression of transgelin 2, and hence could be useful in breast cancer treatments. "
06/01/2015 - "Transgelin: a potentially useful diagnostic marker differentially expressed in triple-negative and non-triple-negative breast cancers."
01/01/2015 - "However, the role of transgelin in different cancers is still very controversial. "
01/01/2015 - "Transgelin is supposed to be a tumor suppression gene and it is down-regulated in a variety of human cancers. "
10/01/2014 - "These results indicate that upregulation of transgelin caused by hypomethylation of the TAGLN gene is closely involved in tumor progression in NF1. "
07/01/2014 - "Proteomic and immunoblot analyses indicated respective 49.88-fold and 25-fold increased levels of transgelin in HM-1 cells compared with that in other non-neuroendocrine cervical cancer cell lines, implying that transgelin is a biomarker for neuroendocrine cervical cancer. "
09/15/2013 - "These findings suggest that transgelin is a potentially useful target protein to modulate PSC function so as to ameliorate pancreatic fibrosis."
01/01/2011 - "The extent of transgelin immunostaining was related to mesangial proliferation (p = 0.034), glomerular sclerosis (p = 0.035), interstitial fibrosis (p = 0.047) and to the clinical course (p = 0.009). "
02/01/2015 - "In this study it was verified that in cultured myoblasts CTGF/CCN2 causes their transdifferentiation into myofibroblasts by up-regulating the expression of fibrosis marker proteins α-smooth muscle actin and transgelin. "
06/01/2008 - "Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis."
12/01/2015 - "Tubular loss was observed with T cell accumulation within the allograft and development of interstitial fibrosis, whilst type III collagen deposition was observed in areas of F4/80(+) macrophages and PDGFR-β(+) and transgelin(+) fibroblasts, all of which were reduced by B cell depletion. "
|4.||Prostatic Neoplasms (Prostate Cancer)
02/01/2010 - "This study aimed to determine whether transgelin expression was suppressed in prostate cancer. "
02/01/2010 - "Thus, transgelin is suppressed during prostate cancer progression and seems to be an important factor in the dysregulation of the actin cytoskeleton."
02/01/2010 - "Similarly, analysis of Affymetrix gene chip data and the Oncomine database indicated that transgelin was one the 2% most significant of all down-regulated genes in response to prostate cancer. "
02/01/2010 - "Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer."
02/01/2007 - "Our findings reveal the novel mechanisms of how transgelin functions as a suppressor to inhibit prostate cancer cell growth. "
10/01/2009 - "Our study demonstrates that CapG and transgelin were preferentially expressed in hPAMSCs under hypoxia compared with normoxia. "
03/15/2014 - "Our findings indicate that HIF-2α upregulates transgelin indirectly and that accumulated TGF-β1 is a mediator in the upregulation of transgelin by HIF-2α under hypoxia. "
03/15/2014 - "A lentiviral vector used to inhibit transgelin expression was constructed and intratracheally instilled in rats 3 wk prior to hypoxia treatment. "
03/15/2014 - "In addition to nonintact cellular migration, inhibition of transgelin expression resulted in impaired proliferation in vitro under hypoxia. "
03/15/2014 - "We previously observed that transgelin was preferentially expressed in human pulmonary arterial smooth muscle cells (PAMSCs) under hypoxia and that the upregulation of transgelin was independent of hypoxia-inducible factor 1α (HIF-1α). "
|2.||salvianolic acid A
|3.||Proteins (Proteins, Gene)
|4.||Actin Capping Proteins
|6.||Messenger RNA (mRNA)
|7.||Carrier Proteins (Binding Protein)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)
|4.||Homologous Transplantation (Allograft)