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pneumococcal surface protein A

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present on nonencapsulated & some encapsulated strains; monoclonal antibodies against it can protect mice from fatal pneumococcal infection

Also Known As:

PspA protein, Streptococcus pneumoniae

Networked: 34 relevant articles (9 outcomes, 4 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58375
  - Bacterial Proteins: 170
    - pneumococcal surface protein A: 34

Experts

1.	Briles, David E: 8 articles (07/2009 - 03/2003)
2.	Briles, D E: 6 articles (07/2005 - 10/2000)
3.	Hollingshead, Susan K: 5 articles (10/2008 - 03/2003)
4.	Miyaji, Eliane N: 3 articles (04/2008 - 09/2002)
5.	Leite, Luciana C C: 3 articles (04/2008 - 09/2002)
6.	Ferreira, Daniela M: 3 articles (04/2008 - 09/2002)
7.	Hollingshead, S K: 3 articles (07/2005 - 12/2000)
8.	Lahdenkari, Mika: 2 articles (10/2008 - 11/2007)
9.	Kilpi, Terhi M: 2 articles (10/2008 - 11/2007)
10.	Darrieux, Michelle: 2 articles (04/2008 - 03/2008)

Related Diseases

1.	Pneumococcal Infections 12/01/2008 - "Protection against systemic fatal pneumococcal infection by maternal intranasal immunization with pneumococcal surface protein A (PspA)." 09/01/2001 - "Pneumococcal surface protein A (PspA) is a pneumococcal virulence factor capable of eliciting protection against pneumococcal infection in mice. " 12/01/2008 - "The aim of this study was to evaluate the protection conferred against fatal pneumococcal infections during infancy by maternal intranasal immunization with pneumococcal surface protein A (PspA). " 10/01/2009 - "Pneumococcal surface protein A (PspA) is highly immunogenic and can induce a protective immune response against pneumococcal infection. " 03/01/2008 - "Pneumococcal surface protein A (PspA) is an important vaccine candidate against pneumococcal infections, capable of inducing protection in different animal models. " Order ALL the reference details at left...
2.	Infection 03/01/2003 - "Pneumococcal surface protein A (PspA) can elicit protection against Streptococcus pneumoniae in mouse infection models. " 04/01/1997 - "Immunization with a plasmid expressing pneumococcal surface protein A (PspA) can elicit protection against fatal infection with Streptococcus pneumoniae." 05/01/2009 - "Immunization of human volunteers with a single dose of pneumococcal surface protein A (PspA) stimulates broad cross-reactive Abs to heterologous PspA molecules that, when transferred, protect mice from fatal infection with Streptococcus pneumoniae. " 12/01/2000 - "Pneumococcal surface protein A (PspA), a cross-reactive protein expressed by all pneumococci, is known to elicit an antibody in animals that can passively protect mice from infection with Streptococcus pneumoniae. " 08/15/2009 - "Pneumococcal surface protein A contributes to secondary Streptococcus pneumoniae infection after influenza virus infection." Order ALL the reference details at left...
3.	Sepsis (Septicemia) 04/01/1997 - "Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae." 12/01/2003 - "Pneumococcal surface protein A is expressed in vivo, and antibodies to PspA are effective for therapy in a murine model of pneumococcal sepsis." 09/01/2001 - "Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. " Order ALL the reference details at left...
4.	Bacteremia 09/01/2001 - "Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. " 09/01/2002 - "We constructed DNA vaccines based on pneumococcal surface protein A (PspA), an antigen shown to induce protection against pneumococcal bacteremia. " Order ALL the reference details at left...
5.	Pneumonia (Pneumonitis) 10/01/2007 - "We assessed pneumococcal surface protein A (PspA) family types of 141 isolates of Streptococcus pneumoniae from community-acquired pneumonia patients in Japan. " 10/01/2007 - "Pneumococcal surface protein A family types of Streptococcus pneumoniae from community-acquired pneumonia patients in Japan." 08/01/2003 - "Using this model of murine pneumonia, we demonstrated that immunization with recombinant forms of either pneumococcal surface protein A (PspA) or PdB (a genetically detoxified derivative of pneumolysin) elicited significant protection against focal pulmonary infection. " 08/01/2003 - "Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Antibodies
2.	Streptococcus pneumoniae plY protein
3.	Antigens
4.	DNA Vaccines
5.	Proteins (Proteins, Gene)
6.	Surface Antigens (Surface Antigen)
7.	Teichoic Acids
8.	Messenger RNA (mRNA)
9.	Phosphorylcholine (Phosphocholine)
10.	Choline (Choline Chloride)

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