MLV 6976

structure given in first source

Also Known As:

4-(2-methylpropyl)-3(3-(perhydroazepin-1-yl))propyl-1,3oxazolidin-2-one; 4-(2-methylpropyl)-3-(3-(perhydroazepin-1-yl)propyl)-5-phenyl-1,3-oxazolidin-2-one; MLV-6976; NC 1200; NC-1200; ipenoxazone hydrochloride; 2-Oxazolidinone, 3-(3-(hexahydro-1H-azepin-1-yl)propyl)-4-(2-methylpropyl)-5-phenyl-, (4S-cis)-

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxazolidinones: 316
        MLV 6976: 2
  - Azepines: 11
    - MLV 6976: 2

Experts

1.	Hosoi, Hiroshi: 1 article (08/2004)
2.	Inoue, Shino: 1 article (08/2004)
3.	Okamoto, Hideyuki: 1 article (08/2004)
4.	Yamanaka, Toshiaki: 1 article (08/2004)

Related Diseases

1.	Tremor (Tremors) 09/01/1986 - "MLV-6976 reduced the severity of harmaline-induced tremor in mice in a dose-dependent manner, but slightly augmented tremorine-induced tremor. "
2.	Vertebrobasilar Insufficiency 08/01/2004 - "To elucidate the effectiveness of the drug in the treatment of vertebrobasilar insufficiency (VBI), we performed an electrophysiological study to examine the effects of ipenoxazone hydrochloride, a glutamate blocker, on hypoxia-induced firing in the medial vestibular nucleus (MVN) neuron, using alpha-chloralose-anesthetized cats. "
3.	Hypoxia (Hypoxemia) 08/01/2004 - "HD and the time to disappearance of firing induced by hypoxia were inhibited by iontophoretic application of ipenoxazone hydrochloride. " 08/01/2004 - "Effect of a glutamate blocker, ipenoxazone hydrochloride on the hypoxia-induced firing in the medial vestibular nucleus." 08/01/2004 - "To elucidate the effectiveness of the drug in the treatment of vertebrobasilar insufficiency (VBI), we performed an electrophysiological study to examine the effects of ipenoxazone hydrochloride, a glutamate blocker, on hypoxia-induced firing in the medial vestibular nucleus (MVN) neuron, using alpha-chloralose-anesthetized cats. "
4.	Vertigo (Positional Vertigo) 08/01/2004 - "These results suggest that ipenoxazone hydrochloride protects against hypoxic neuronal dysfunction, and may be an effective drug for vertigo caused by VBI."
5.	Decerebrate State 09/01/1986 - "Normal rats and mice receiving MLV-6976 at doses which reduced decerebrate rigidity showed no behavioural changes, impairment of motor coordination only appearing at extremely high doses. "

Related Drugs and Biologics

1.	Tremorine
2.	Harmaline
3.	Glutamic Acid (Glutamate)
4.	Chloralose