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aditoprim

structure given in first source

Also Known As:

2,4-diamino-5-(4-(dimethylamino)-3,5-dimethoxybenzyl)pyrimidine

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Trimethoprim: 2082
      - aditoprim: 7

Experts

1.	Huang, Lingli: 4 articles (03/2022 - 12/2015)
2.	Xie, Shuyu: 3 articles (03/2022 - 02/2020)
3.	Yuan, Zonghui: 3 articles (03/2022 - 12/2015)
4.	Pan, Yuanhu: 2 articles (03/2022 - 12/2015)
5.	Ahmed, Saeed: 2 articles (01/2021 - 02/2020)
6.	Maan, Muhammad Kashif: 2 articles (01/2021 - 02/2020)
7.	Mi, Kun: 2 articles (01/2021 - 02/2020)
8.	Sattar, Adeel: 2 articles (01/2021 - 02/2020)
9.	Xin, Li: 2 articles (01/2021 - 02/2020)
10.	Dong, Mengxiao: 1 article (03/2022)

Related Diseases

1.	Infections 03/28/2022 - "In order to effectively treat the infection of Streptococcus suis and reduce the emergence of drug-resistant bacteria, an aditoprim (ADP) injection was developed in this study. "
2.	Endometritis 02/24/2020 - "Integration of PK/PD for dose optimization of aditoprim against Trueperella pyogenes causing endometritis in bovines." 01/01/2021 - "Dose Optimization of Aditoprim-Sulfamethoxazole Combinations Against Trueperella pyogenes From Patients With Clinical Endometritis by Using Semi-mechanistic PK/PD Model."
3.	Body Weight (Weight, Body) 12/01/2015 - "The no-observed-adverse-effect level for reproduction/development toxicity of aditoprim was 100 mg kg(-1) diet (about 7.89-9.25 mg kg(-1) body weight day(-1) )." 12/01/1992 - "A single dose of 5 mg of aditoprim/kg of body weight was administered IV to 5 healthy cows and to the same cows 3 weeks later at 2 hours after intramammary infusion of 0.1 mg of endotoxin into the rear quarters. "
4.	Respiratory Tract Infections (Respiratory Tract Infection) 09/27/2022 - "The new drug Aditoprim (ADP) alone or combined with Sulfamethoxazole (SMZ) is one of the good choices for treating respiratory infections. "
5.	Mastitis 12/01/1992 - "The lower plasma concentrations of aditoprim between 5 and 26 hours after injection in cows with mastitis are explained by fluid compartment shifts and/or blood flow changes induced by mastitis, although increased elimination of aditoprim in cows with mastitis cannot completely be ruled out. " 12/01/1992 - "In cows with mastitis, plasma concentrations of aditoprim were lower between 5 and 26 hours after injection. " 12/01/1992 - "Effects of endotoxin-induced mastitis on the pharmacokinetic properties of aditoprim in dairy cows." 12/01/1992 - "Plasma disposition of aditoprim, a new dihydrofolate reductase inhibitor, was studied in healthy cows and cows with endotoxin-induced mastitis. "

Related Drugs and Biologics

1.	Adenosine Diphosphate (ADP)
2.	Sulfamethoxazole
3.	Trimethoprim (Proloprim)
4.	Folic Acid Antagonists
5.	Endotoxins