|1.||Doolittle, Gary C: 1 article (02/2002)|
|2.||Flaherty, Lawrence E: 1 article (02/2002)|
|3.||Whitehead, Robert P: 1 article (02/2002)|
|4.||Klein, Catherine E: 1 article (02/2002)|
|5.||Hammond, Neel: 1 article (02/2002)|
|6.||Chapman, Robert A: 1 article (02/2002)|
|7.||Unger, Joseph M: 1 article (02/2002)|
|8.||Kraut, Eric H: 1 article (02/2002)|
|9.||Southwest Oncology Group: 1 article (02/2002)|
|10.||Sondak, Vernon K: 1 article (02/2002)|
10/15/1993 - "Phase I evaluation and pharmacokinetic study of pyrazine-2-diazohydroxide administered as a single bolus intravenous injection in patients with advanced solid tumors."
12/01/1987 - "The synthesis, chemical stability and anti-tumor activity of pyrazine diazohydroxide, sodium salt, a compound that has been selected for development to clinical trials, are described. "
07/01/2011 - "(AIC is formed in amounts equimolar to the active alkylating moiety, methane diazohydroxide, which is undetectable by known validated assays.) Patients with advanced solid tumors received intravenous dacarbazine 1,000 mg/m(2) on day 1 of a 21-day cycle to evaluate the PK of dacarbazine alone. "
12/01/1987 - "Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456)."
02/01/2002 - "Pyrazine diazohydroxide (PZDH) is a new agent inhibiting DNA synthesis that is active in mouse tumor models and human xenografts and lacks cross resistance with multiple standard agents. "
|2.||Colorectal Neoplasms (Colorectal Cancer)
|3.||Prostatic Neoplasms (Prostate Cancer)
|4.||Melanoma (Melanoma, Malignant)
02/01/2002 - "Pyrazine diazohydroxide by this dose and schedule has insufficient activity in the treatment of disseminated malignant melanoma to warrant further investigation."
02/01/2002 - "A phase II trial of pyrazine diazohydroxide in patients with disseminated malignant melanoma and no prior chemotherapy--Southwest Oncology Group study."
|5.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
|3.||DNA (Deoxyribonucleic Acid)
|2.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)