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siagoside
internal ester of GM1
Also Known As:
AGF-2; AGF2 ganglioside; ganglioside AGF2
Networked:
5
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Carbohydrates: 22023
Glycoconjugates: 1353
Glycolipids: 2799
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
G(M1) Ganglioside: 444
siagoside: 5
Lipids: 114793
Glycolipids: 2799
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
G(M1) Ganglioside: 444
siagoside: 5
Membrane Lipids: 1591
Sphingolipids: 3208
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
G(M1) Ganglioside: 444
siagoside: 5
Related Diseases
1.
Brain Edema (Cerebral Edema)
01/01/1989 - "
Ganglioside treatment was effective in reducing the increase of cerebral water content, nonetheless AGF-2 reduces significantly not only cerebral edema, but also potassium efflux and calcium overload.
"
2.
Cognitive Dysfunction
06/01/1991 - "
Ganglioside AGF2 prevents the cognitive impairments and cholinergic cell loss following intraventricular colchicine.
"
09/17/1990 - "
Ganglioside AGF2 attenuated both the cognitive impairments and the cholinergic hypofunction induced by ethylcholine aziridinium ion (AF64A).
"
3.
Ischemia
02/01/1992 - "
Siagoside selectively attenuates morphological and functional striatal impairments induced by transient forebrain ischemia in rats.
"
10/01/1993 - "
Pretreatment with the ganglioside AGF2 prevented the redistribution of PKC (gamma) in the particulate fraction at 5 min, but not at 10 min of ischemia.
"
4.
Brain Ischemia (Cerebral Ischemia)
02/01/1992 - "
Daily siagoside treatment after acute cerebral ischemia attenuates some morphological and functional deficits related to striatal damage.
"
02/01/1992 - "
siagoside starting 4 hours after the cerebral ischemia.
"
01/01/1989 - "
In conclusion, these results suggest that, except in some cases with different potency, both monosialoganglioside GM-1 and its inner ester derivative, AGF-2, are able to improve outcome after brain ischemia.
"
Related Drugs and Biologics
1.
Potassium
2.
Gangliosides
3.
Calcium
4.
Cholinergic Agents (Cholinergics)
5.
Esters
6.
Dihydrotachysterol (AT 10)
7.
Colchicine
8.
protein kinase C gamma (PRKCG)
9.
ethylcholine aziridinium