kallistatin

from human serum, lung fibroblast conditioned media, rodent neuroblastoma; belong to serpin superfamily; RefSeq NM_006215 (SERPINA4, human); NM_145097 (Serpina4, rat); do not confuse with KBP kinesin-binding protein, rat

Also Known As:

KBP protein, rat; SERPIN-A4; SERPINA3K protein, human; SERPINA4 protein, human; Serpina4 protein, rat; TKBP; kallikrein-binding protein, human; kallikrein-binding protein, rat; kallistatin protein, human; kallistatin protein, rat; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 protein, human; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 protein, rat; tissue kallikrein-binding protein

Networked: 128 relevant articles (18 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chao, Julie: 35 articles (12/2021 - 09/2002)
2.	Chao, Lee: 33 articles (11/2018 - 11/2002)
3.	Li, Pengfei: 12 articles (11/2018 - 07/2013)
4.	Guo, Youming: 9 articles (11/2018 - 05/2015)
5.	Diao, Yong: 9 articles (01/2018 - 09/2007)
6.	Bledsoe, Grant: 9 articles (01/2017 - 11/2010)
7.	Shen, Bo: 7 articles (09/2014 - 12/2006)
8.	Ma, Jian-Xing: 5 articles (01/2021 - 09/2010)
9.	Gao, Lin: 5 articles (01/2017 - 11/2008)
10.	Wu, Chao-Liang: 5 articles (09/2015 - 04/2005)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "This study explored the new target of treatment of HF by investigating the effect of Kallistatin (KS) on inflammation and apoptosis of myocardial tissue in HF rats. " 03/15/2023 - "Administration of kallistatin remarkably inhibited RA development, accompanied by reduced inflammation and apoptosis. " 03/15/2023 - "In summary, kallistatin suppressed IL-1β-mediated inflammation in chondrocytes via the NF-κB pathway. " 03/15/2023 - "Furthermore, kallistatin markedly suppressed IL-1β-mediated inflammation while decreasing the levels of inflammatory factors and mediators via the NF-κB pathway. " 12/01/2021 - "Conversely, overexpression of kallistatin attenuated renal inflammation, interstitial fibroblast activation and tubular injury in UUO mice. "
2.	Neoplasms (Cancer) 01/01/2017 - "These findings reveal novel mechanisms of kallistatin in protection against senescence, aging, and cancer development by modulating miR-34a and miR-21 levels and inhibiting oxidative stress." 01/01/2016 - "In addition, multiple studies demonstrated that kallistatin directly inhibits cancer cell growth. " 05/31/2010 - "Results of this study showed that systemic administration of lentiviral vectors encoding kallistatin inhibited the growth of metastatic tumor and prolonged the survival of tumor-bearing mice. " 01/01/2021 - "Recombinant Adeno-associated Virus 9-mediated Expression of Kallistatin Suppresses Lung Tumor Growth in Mice." 01/05/2018 - "These findings provide mechanistic insights into the inhibitory effects of kallistatin on endothelial cell growth, tumor cell proliferation, and tumor-related angiogenesis."
3.	Vascular System Injuries 11/01/2010 - "These findings indicate a novel role of kallistatin in the protection against vascular injury and oxidative stress-induced endothelial apoptosis via the activation of Akt-dependent eNOS signaling." 11/01/2010 - "The present study was aimed to investigate the role and mechanisms of kallistatin in protection against oxidative stress-induced vascular injury and endothelial cell apoptosis. " 08/01/2010 - "This study identifies a protective role of kallistatin in vascular injury, thereby implicating the therapeutic potential of kallistatin for vascular and inflammatory diseases." 01/01/2018 - "These findings indicate that endogenous kallistatin displays a novel role in protection against vascular injury and senescence by inhibiting oxidative stress and inflammation." 01/01/2018 - "Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation."
4.	Sepsis (Septicemia) 07/22/2015 - "These findings suggest the therapeutic potential of kallistatin for sepsis-related ALI/ARDS. " 05/01/2015 - "The effect of kallistatin treatment on organ damage was examined one day after sepsis initiation, and mouse survival was monitored for four to six days. " 05/01/2015 - "Here, we investigated the effect of kallistatin on survival and organ damage in mouse models of established sepsis. " 05/01/2015 - "Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis." 06/01/2014 - "Here, we investigated the effects of human kallistatin on organ injury and survival in a mouse model of polymicrobial sepsis. "
5.	Myocardial Infarction 12/01/2006 - "Kallistatin gene transfer significantly reduced myocardial infarct size and left ventricle end-diastolic pressure and improved cardiac contractility. " 11/01/2008 - "Kallistatin administration improved cardiac performance, increased mean arterial pressure, decreased myocardial infarct size and restored left ventricular wall thickness. " 11/01/2008 - "Role of kallistatin in prevention of cardiac remodeling after chronic myocardial infarction." 01/01/2022 - "Human kallistatin (KS, mouse Serpina3c homologs) inhibits fibrosis after myocardial infarction (MI) but the specific underlying mechanism is unknown. " 01/01/2022 - "Kallistatin/Serpina3c inhibits cardiac fibrosis after myocardial infarction by regulating glycolysis via Nr4a1 activation."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Kallikreins (Kallikrein)
3.	Antioxidants
4.	Simvastatin (Zocor)
5.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Urea (Carbamide)
8.	Phosphatidylinositols (Phosphatidylinositol)
9.	Nitrogen
10.	Catenins

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Therapeutics
4.	Gastric Bypass (Roux-en-Y Gastric Bypass)
5.	Intravenous Injections