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O-alkyl cleavage enzyme
Also Known As:
ALP hydrolase; alkyl-lysophospholipid hydrolase
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
O-alkyl cleavage enzyme: 2
Related Diseases
1.
Neoplasms (Cancer)
02/01/1983 - "
Preincubation of ALP (rac-1-octadecyl-lyso-glycero-3-phosphocholine) for more than 8 min with a tetrahydropteridine-dependent O-alkyl cleavage enzyme preparation from rat liver microsomes destroyed almost all of the cytotoxic properties of ALP when tested at a concentration that previously inhibited tumor growth by more than 50%.
"
2.
Leukemia
02/01/1987 - "
In comparison to an approximate sevenfold to elevenfold (ID50 and LD50, respectively) difference in the susceptibility of the above leukemia cell lines to ET-18-OCH3, no significant difference in the specific activities (0.13-0.21 nmol/min/mg) of the O-alkyl cleavage enzyme was found in the above leukemia cell lines.
"
02/01/1987 - "
Sensitivity of leukemia cell lines to cytotoxic alkyl-lysophospholipids in relation to O-alkyl cleavage enzyme activities.
"
Related Drugs and Biologics
1.
Lysophospholipids
2.
5,6,7,8-tetrahydropteridine
3.
edelfosine