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N- (1- carboxy- 3- carboxanilidopropyl)alanylproline

structure given in first source

Also Known As:

RAC X 65; RAC-X-65

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - Enalapril: 3647
        N-(1-carboxy-3-carboxanilidopropyl)alanylproline: 1

Related Diseases

1.

Hypertension (High Blood Pressure)

01/01/1986 - "That such tightly bound complexes are formed in vivo is suggested by the following results: The intravenous ED50 (anesthetized rats) of RAC-X-65 is 9.43 nmol/kg, and the time for half recovery (t1/2) of responsiveness to i.v. angiotensin I, 120 ng/kg, following a cumulative dose of 240 nmol/kg of the inhibitor is 165 min. For comparison, the i.v. ED50 of captopril is 105 nmol/kg, and its t1/2 following a cumulative dose of 240 nmol/kg is 16 min. Implied is the possibility that slow tight binding inhibitors of ACE may be used in a 1 pill per day regimen for the treatment of hypertension."

Related Drugs and Biologics

1.	Captopril (Capoten)
2.	Angiotensin I