doqualast

11/01/1986 - "Above findings suggest that Sm 857 may be useful for the treatment of bronchial asthma as an orally active drug, exerting its action probably through a mast cell stabilizing effect."
11/01/1986 - "From these results it may be concluded that Sm 857 exerts preferential effect on the respiratory system and that it might be useful in allergic asthma."
11/01/1986 - "Intravenous administration of Sm 857 (10 mg/kg) also strongly inhibited the Ascaris-induced bronchial asthma. "
11/01/1986 - "Both oral and intravenous administration of Sm 857 showed an inhibitory effect on experimental asthma in guinea pigs, which was similar to that of tranilast."
11/01/1986 - "[Protective effect of Sm 857 (Doqualast) in allergic bronchial asthma]."

11/01/1986 - "The effects of 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid (Sm 857) on immediate type, particularly type I allergic reactions were investigated and the following results were obtained. "
11/01/1986 - "A new chemical compound, 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid (Sm 857), known to inhibit the second stage type I allergy and endowed with antiasthmatic action, was investigated with regard to its effects on theophylline (TP) blood level in comparison with ketotifen and tranilast, antiasthmatics of the same therapeutic category as Sm 857, and tiaramide, an antiinflammatory agent. "

11/01/1986 - "4. Passive systemic anaphylaxis in guinea pigs was not inhibited at 50-200 mg/kg (p.o.) of Sm 857. "
11/01/1986 - "3. Cutaneous anaphylaxis and histamine-induced cutaneous reaction in guinea pigs were hardly affected by the treatment of 50 and 100 mg/kg (p.o.) of Sm 857. "
11/01/1986 - "The effects of 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid (Sm 857), a new antiallergic drug, on both bronchial asthma and active cutaneous anaphylaxis (ACA) reaction induced by Ascaris suum antigen in dogs were investigated. "

09/01/1989 - "[Pilot study of the action of Doqualast on dietary hyperuricemia in volunteers]."

11/01/1986 - "Sm 857 did not inhibit ultraviolet-induced erythema in guinea pigs, intradermal increased vascular permeability induced by histamine in rats and carrageenin-induced edema of the rat hind paw. "