prothrombin Tokushima

mutant prothrombin from plasma of proband with only 12% normal clotting activity & 42% normal prothrombin antigen; arginine is replaced by tryptophan at position 418

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Irahara, Minoru: 1 article (10/2015)
2.	Kaji, Takashi: 1 article (10/2015)
3.	Kasai, Kana: 1 article (10/2015)
4.	Maeda, Kazuhisa: 1 article (10/2015)
5.	Morine, Mikio: 1 article (10/2015)
6.	Nakayama, Soichiro: 1 article (10/2015)

Related Diseases

1.	Dysprothrombinemia 10/01/2015 - "A case of pregnancy complicated with congenital dysprothrombinemia (prothrombin Tokushima)." 09/01/1987 - "[Dysprothrombinemia--with special reference to prothrombin Tokushima]." 12/01/1992 - "Molecular and genetic analysis of a compound heterozygote for dysprothrombinemia of prothrombin Tokushima and hypoprothrombinemia." 12/01/1992 - "A single nucleotide substitution responsible for dysprothrombinemia of prothrombin Tokushima was detected, as were three polymorphisms. "
2.	Hypoprothrombinemias (Prothrombin Deficiency) 12/01/1992 - "Molecular and genetic analysis of a compound heterozygote for dysprothrombinemia of prothrombin Tokushima and hypoprothrombinemia."
3.	Hemorrhage 02/24/1987 - "The Arg----Trp replacement found in the thrombin portion of prothrombin Tokushima appears to reduce its interaction with various substrates including fibrinogen and platelet receptors and accounts for the recurrent bleeding episode observed in the propositus."

Related Drugs and Biologics

1.	Thrombin
2.	Nucleotides
3.	Fibrinogen (Factor I)