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spiradoline

RN given refers to (5alpha,7alpha,8beta)-(+-)-isomer; structure given in first source

Also Known As:

U 62066; U-62,066E; U62,066E

Networked: 24 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - spiradoline: 24

Experts

1.	France, Charles P: 2 articles (01/2018 - 02/2017)
2.	Minervini, Vanessa: 2 articles (01/2018 - 02/2017)
3.	Lu, Hannah Y: 1 article (01/2018)
4.	Osteicoechea, Daniela C: 1 article (01/2018)
5.	Padarti, Jahnavi: 1 article (01/2018)
6.	Dahal, Sujata: 1 article (02/2017)
7.	Briggs, Shannon L: 1 article (01/2012)
8.	Mokler, David J: 1 article (01/2012)
9.	Rech, Richard H: 1 article (01/2012)
10.	Huang, Fen-Sheng: 1 article (10/2008)

Related Diseases

1.	Shock 01/01/1991 - "Separate groups of rats were trained to discriminate between SC injections of saline and either 3.0 mg/kg spiradoline or 3.0 mg/kg morphine in a discrete-trial shock-avoidance/escape procedure. " 12/01/1994 - "These results parallel those previously obtained with other kappa agonists, such as bremazocine and U50,488 and suggest that the antinociceptive effects of spiradoline, enadoline and U69,593 in the shock-titration procedure in squirrel monkeys relate to activity at non-mu, probably kappa, opioid receptors." 03/01/1997 - "Flumazenil, Ro 15-4513, pentylenetetrazole, betaCCE but not ketamine or spiradoline decreased rates of responding in the food component at doses that had little effect on rates in the stimulus-shock termination component. " 12/01/1994 - "Effects of the kappa opioid agonists, spiradoline (U62,066), enadoline (CI-977) and U69,593, were examined alone and in combination with the opioid antagonists quadazocine and beta-funaltrexamine in squirrel monkeys that responded under a schedule of shock titration. "
2.	Hypertension (High Blood Pressure) 01/01/2001 - "Animals treated with U62, 066E did not develop hypertension as compared to isolated animals treated with vehicle. " 04/01/1999 - "The object of the present study was to determine whether U62,066E, a non-peptide kappa agonist, would lower BP in another animal model of hypertension; that produced by isolation of young male rats. " 01/01/2001 - "This time is increased by U62, 066E, suggesting that the drug possesses anxiolytic properties and may reduce hypertension in part, by blocking an anxiety/stress component. "
3.	Tourette Syndrome (Tourette's Syndrome) 06/01/1993 - "Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: a pilot study." 01/01/2003 - "At low doses spiradoline was reported to decrease tics in patients with Tourette's syndrome. " 06/01/1993 - "To evaluate the role of opioids in Tourette's syndrome (TS), we performed a dose-response study of the behavioral and neuroendocrine effects of the selective kappa agonist spiradoline mesylate (U-62066E) in five TS patients and five normal control subjects, aged 20 to 47. "
4.	Hypoglycemia (Reactive Hypoglycemia) 12/05/1994 - "Both U-50,488H and U-62,066E exhibited an attenuating effect on hypoxia/hypoglycemia-induced reduction in 2-DG uptake of hippocampal slices. " 12/05/1994 - "The aim of the present study was to determine whether U-50,488H and U-62,066E, kappa-opioid receptor agonists cause a neuroprotective action against hypoxia/hypoglycemia-induced reduction in 2-deoxyglucose (2-DG) uptake of hippocampal slices from U-50,488H-tolerant rats. "
5.	Hypoxia (Hypoxemia) 12/05/1994 - "Both U-50,488H and U-62,066E exhibited an attenuating effect on hypoxia/hypoglycemia-induced reduction in 2-DG uptake of hippocampal slices. " 12/05/1994 - "The aim of the present study was to determine whether U-50,488H and U-62,066E, kappa-opioid receptor agonists cause a neuroprotective action against hypoxia/hypoglycemia-induced reduction in 2-deoxyglucose (2-DG) uptake of hippocampal slices from U-50,488H-tolerant rats. "

Related Drugs and Biologics

1.	kappa Opioid Receptors (kappa Opioid Receptor)
2.	(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide
3.	Mesylates (Mesylate)
4.	Morphine (MS Contin)
5.	Opioid Analgesics (Opioids)
6.	Peptides (Polypeptides)
7.	Deoxyglucose (2 Deoxy D glucose)
8.	mu Opioid Receptors (mu Opioid Receptor)
9.	Salts
10.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Injections
2.	Therapeutics
3.	Ligation