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N,N'- bis(2- ethyl- 1,3- dioxolane)kryptocyanine

potential photochemotherapy agent; structure given in first source
Also Known As:
EDKC
Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1. Carcinoma (Carcinomatosis)
09/01/1990 - "A series of nontumorigenic and tumorigenic human bronchial epithelial and human pleural mesothelial cells were assayed for EDKC uptake and retention, with the intent of using selective carcinoma cell photolysis to isolate nontumorigenic revertants of the tumorigenic lung cell lines. "
07/01/1987 - "We have evaluated several classes of cationic dyes, and in the case of N,N'-bis-(2-ethyl-1,3-dioxolane)-kryptocyanine (EDKC) and some of its analogs, have demonstrated highly selective killing of human squamous cell, bladder and colon carcinoma cells in vitro. "
12/15/1987 - "We investigated mechanisms of mitochondrial phototoxicity caused by the cationic cyanine dye N,N'-bis(2-ethyl-1,3-dioxylene)kryptocyanine (EDKC), examining the role of the mitochondrial membrane potential on the dye uptake by carcinoma cells in vitro, and both the dark and photosensitizing effects of the dye on the function of isolated mouse liver mitochondria. "
12/15/1987 - "When human bladder carcinoma cells (EJ) were pretreated with 2,4-dinitrophenol or nigericin, cellular uptake of EDKC decreased or increased, respectively, consistent with dye uptake that is dependent on membrane potentials. "
12/01/1986 - "The most effective, N,N'-bis(2-ethyl-1,3-dioxolane)kryptocyanine (EDKC), caused marked, light-dependent killing of human bladder, squamous, and colon carcinoma cell lines after 30-min incubations at 1-0.01 microM but was minimally toxic to human keratinocytes and to normal monkey kidney epithelial cells (CV-1). "
2. Phototoxic Dermatitis (Phototoxicity)
3. Photosensitivity Disorders (Photodermatitis)
4. Neoplasms (Cancer)

Related Drugs and Biologics

1. N,N'- bis(2- ethyl- 1,3- dioxolane)kryptocyanine
2. Photosensitizing Agents (Photosensitizers)
3. Coloring Agents (Dyes)
4. 2,4-Dinitrophenol (2,4 Dinitrophenol)
5. Nigericin
6. Cytotoxins
7. cyanine dye (betacyanin)
8. kryptocyanine