OPAL protocol

chemotherapy protocol consisting of above 4 cpds; used in the treatment of acute lymphoblastic leukemia

Also Known As:

L-AdVP

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - OPAL protocol: 1
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - OPAL protocol: 1
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - OPAL protocol: 1
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Amidohydrolases: 43
      - Asparaginase: 2285
        OPAL protocol: 1
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Anthracyclines: 9423
        Daunorubicin: 2641
        Doxorubicin: 35390
        OPAL protocol: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        OPAL protocol: 1
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienetriols
        Prednisolone: 12013
        OPAL protocol: 1
Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        OPAL protocol: 1
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - Vinca Alkaloids: 463
        Vincristine: 9251
        OPAL protocol: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        Vincristine: 9251
        OPAL protocol: 1
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        Vincristine: 9251
        OPAL protocol: 1

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/1994 - "A randomized clinical trial of combination chemotherapy for adult acute lymphoblastic leukemia (ALL) with doxorubicin, vincristine and prednisolone with and without L-asparaginase (AdVP vs L-AdVP) was conducted, involving 58 institutions throughout Japan. "
2.	Pancreatitis 01/01/1994 - "As to adverse effects, pancreatitis was complicated more frequently in L-AdVP than in AdVP (P = 0.039). "
3.	Hyperbilirubinemia 01/01/1994 - "Other side effects such as hyperbilirubinemia, diabetes mellitus, diarrhea and hypofibrinogenemia were observed more frequently with L-AdVP, but with no statistical significance. "
4.	Diarrhea 01/01/1994 - "Other side effects such as hyperbilirubinemia, diabetes mellitus, diarrhea and hypofibrinogenemia were observed more frequently with L-AdVP, but with no statistical significance. "
5.	Diabetes Mellitus 01/01/1994 - "Other side effects such as hyperbilirubinemia, diabetes mellitus, diarrhea and hypofibrinogenemia were observed more frequently with L-AdVP, but with no statistical significance. "

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	Prednisolone (Predate)
3.	Doxorubicin (Adriamycin)
4.	Asparaginase (Elspar)

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)