DNA alkyltransferase

involved in DNA repair by conversion of O(6)-alkylguanine & O(4)-alkylthymine to the normal bases; see also EC, O(6)-methylguanine-DNA methyltransferase
Also Known As:
alkylated DNA alkyltransferase
Networked: 44 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Gerson, Stanton L: 5 articles (05/2012 - 05/2002)
2. Liu, Lili: 3 articles (05/2012 - 09/2002)
3. Zalutsky, Michael R: 2 articles (01/2011 - 04/2006)
4. Vaidyanathan, Ganesan: 2 articles (01/2011 - 04/2006)
5. Margison, G P: 2 articles (03/2007 - 06/2002)
6. Gerson, S L: 2 articles (08/2001 - 05/2001)
7. Vettone, Antonella: 1 article (09/2014)
8. Rossi, Mosè: 1 article (09/2014)
9. Valenti, Anna: 1 article (09/2014)
10. Perugino, Giuseppe: 1 article (09/2014)

Related Diseases

1. Neoplasms (Cancer)
2. Lung Neoplasms (Lung Cancer)
3. Brain Neoplasms (Brain Tumor)
04/01/1989 - "The level of O6-alkylguanine-deoxyribonucleic acid (DNA) alkyltransferase (AT) was determined in 15 human brain-tumor xenografts in athymic mice. "
03/15/1995 - "p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors."
03/15/1995 - "In human brain tumors, sensitivity to procarbazine as measured by sensitivity in a xenograft tumor model correlated inversely with amounts of the DNA repair enzyme O6-alkylguanine DNA alkyltransferase (AT). "
01/01/1996 - "Much of the progress made to date, however, has resulted, in part from advances in the ability to culture and propagate cells of both normal and neoplastic brain tissue in vitro (2, 3) For example, in vitro cultures have contributed significantly to the development of techniques, such as bromodeoxyuridine labeling, that are used to estimate the cell-growth kinetics of gliomas in patients (4) Normal brain and brain tumor cultures have also played a central role in research directed at a better understanding of the complex interplay between the cellular components of the brain, such as that between various glial cells, neurons, and endothelial cells (5, 6) In studies of the molecular and cellular mechanisms involved in brain tumor resistance to therapy, in vitro cultures of human glioma cells have played a significant role in the identification of O(6)-alkylguanine DNA alkyltransferase (7), glutathione, and glutathione S-transferases (8), as critical factors in human brain tumor alkylator resistance, findings that are providing the basis for novel therapies for human gliomas. "
4. Melanoma (Melanoma, Malignant)
5. Glioma (Gliomas)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. O(6)-benzylguanine
3. Carmustine (FIVB)
4. temozolomide (Temodar)
5. Transferases
6. Nitrosamines
7. Glutathione (Reduced Glutathione)
8. Bromodeoxyuridine (BrdU)
9. lomeguatrib
10. Guanine

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Heterologous Transplantation (Xenotransplantation)
3. Splenectomy
4. Aftercare (After-Treatment)