05/01/1989 - "Pre-S proteins in hepatitis B."
11/01/1987 - "[Pre-S proteins in hepatitis B]."
07/01/1988 - "This study confirmed the high amount of pre-S proteins as well as poly-albumin receptors in purified Dane particles and sera of patients with acute hepatitis B. "
05/01/1987 - "Quantitative studies of the hepatitis B viral pre-S proteins: lack of correlation with the HBeAg status."
05/09/1985 - "The results presented here provide unambiguous evidence that all three env encoded proteins are present in HBV particles; synthetic peptides corresponding to the gene encoding pre-S are highly immunogenic and can be used in diagnostic tests for detection in human sera of antibodies preferentially recognizing HBV; such antibodies, specific for pre-S determinants, are elicited during hepatitis B infection and by immunization with HBV proteins (2) and (3); the hepatitis B vaccine licensed in the United States does not contain pre-S proteins; and the pre-S proteins of the HBV envelope contain domains specifically recognized by liver cells. "
10/01/1989 - "These results indicate that pre-S proteins in serum and the membranous display of pre-S2 on hepatocytes of patients with chronic HBV infection refect active viral replication, but their expression does not correlate with disease activity."
10/01/1989 - "Therefore, we studied the expression of pre-S proteins in the liver and serum of 26 patients with chronic HBV infection, using immunoperoxidase staining and enzyme immunoassay. "
06/01/1989 - "Our results also indicated that pre-S proteins expression in serum can serve as markers of HBV infection, but cannot be used to estimate the severity and activity of hepatic pathology."
06/01/1989 - "However, the frequency was slightly higher in liver than in serum, suggesting that it may be clinically valuable to detect pre-S proteins in serum and liver simultaneously to determine the status of HBV infection. "
06/01/1989 - "Furthermore, it reached 87.8% and 77.6%, respectively, in cases with chronic HBV infection, indicating that pre-S proteins are usually expressed in sera with chronic HBV infection. "
|3.||Chronic Hepatitis B
10/01/1989 - "Pre-S proteins in chronic hepatitis B virus infection: markers of active viral infection."
03/01/1994 - "Deletion mutants of hepatitis B virus (HBV) pre-S proteins were detected in serum in 2 of 10 (20%) individuals with chronic hepatitis B infection following the initiation of interferon treatment. "
06/01/1989 - "To assess the significance of pre-S proteins expression during chronic hepatitis B virus (HBV) infection, we developed a sensitive labeled avidin biotin ELISA to detect pre-S1 and pre-S2 proteins. "
08/01/1989 - "In chronic viral type B hepatitis, the presence in the serum of pre-S proteins of hepatitis B virus (HBV) envelope reflects viral replication. "
05/01/1987 - "Contrary to previously published data, it was found that there is no correlation between the presence of the pre-S proteins and the HBeAg status of the plasma, but that the ability to detect the pre-S proteins is only a function of the hepatitis surface antigen titre of the plasma. "
12/01/1989 - "Intrahepatic expression of pre-S proteins of hepatitis B virus and its possible relation to liver cell necrosis."
12/01/1989 - "In conjunction with these data, we conclude that, as the essential components of HBV envelope proteins, pre-S proteins may play an important role in resulting in liver cell necrosis."
|1.||Hepatitis B e Antigens
|3.||Proteins (Proteins, Gene)
|4.||DNA (Deoxyribonucleic Acid)
|5.||Hepatitis B Vaccines (Hepatitis B Vaccine)
|8.||Hepatitis B Core Antigens