pyridoxalated-hemoglobin-polyethylene glycol conjugate

Also Known As:

PHP conjugate; PHP44 conjugate; PHP88 conjugate; PLP-Hb-PEG; POE conjugated pyridoxalated hemoglobin; polyoxyethylene conjugated pyridoxalate hemoglobin; pyridoxalated-hemoglobin-polyoxyethylene conjugate; pyridoxylated haemoglobin-polyoxyethylene conjugate; pyridoxylated hemoglobin-polyoxyethylene conjugated solution

Networked: 12 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Talarico, T L: 2 articles (05/2000 - 01/2000)
2.	Vaslef, Steven N: 1 article (01/2004)
3.	Wirk, Shaheen: 1 article (01/2004)
4.	Baldwin, A: 1 article (04/2001)
5.	Wiley, E: 1 article (04/2001)
6.	DeAngelo, J: 1 article (05/2000)
7.	Keng, T: 1 article (05/2000)
8.	Privalle, C: 1 article (05/2000)
9.	Talarico, T: 1 article (05/2000)
10.	Eachempati, S R: 1 article (05/2000)

Related Diseases

1.	Shock 05/15/2000 - "One such product, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), is a human-derived and chemically modified hemoglobin that has yielded promising results in Phase II clinical trials, and is entering a pivotal Phase III clinical trial for the treatment of shock associated with systemic inflammatory response syndrome (SIRS). " 12/15/1999 - "Pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), a modified human-derived hemoglobin, is currently in clinical trials as a nitrogen monoxide scavenger for the treatment of shock. " 01/03/2000 - "Pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) was developed in the 1980s as an oxygen carrier and is now under development for treatment of nitric oxide-dependent, volume refractory shock. " 04/01/2001 - "VitaResc (formerly Apex) is developing PHP-HT, pyridoxalated hemoglobin polyoxyethylene conjugate, for the potential treatment of nitric oxide-induced shock (characterized by hypotension), associated with various etiologies, initially in septic shock. "
2.	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 05/15/2000 - "One such product, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), is a human-derived and chemically modified hemoglobin that has yielded promising results in Phase II clinical trials, and is entering a pivotal Phase III clinical trial for the treatment of shock associated with systemic inflammatory response syndrome (SIRS). "
3.	Hemorrhage 01/01/2004 - "Pyridoxalated hemoglobin polyoxyethylene conjugate is at least as effective as shed blood in restoring hemodynamic balance and oxygen delivery after moderate hemorrhage. " 05/01/2000 - "Fifteen swine underwent hemorrhage and equal volume resuscitation with pyridoxalated hemoglobin polyoxyethylene conjugate containing 0% or 8% maltose, or low P50 conjugate, which also contained 8% maltose. " 01/01/2004 - "Pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), a hemoglobin-based oxygen carrier, is effective in restoring hemodynamic balance and oxygen delivery after moderate hemorrhage but may be less effective in off-loading oxygen at the tissue level. "
4.	Sepsis (Septicemia) 06/01/1997 - "In this study, we determined the effects of different doses of the modified human pyridoxalated hemoglobin polyoxyethylene conjugate in an ovine model of hyperdynamic sepsis. " 07/01/1998 - "Animals that survived the first 24 h of sepsis (n=12) were randomly assigned either to a treatment group that received 20 mg x kg(-1) x h(-1) pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) for 20 h or to a control group that received the same volume of the vehicle for 20 h. " 09/01/1997 - "Pulmonary arterial pressure was increased during sepsis and increased even further after pyridoxalated hemoglobin polyoxyethylene conjugate administration. " 09/01/1997 - "Nineteen female merino sheep, divided into three groups: group 1, controls (n = 5); group 2, sheep with sepsis (n = 6); and group 3, septic sheep treated with pyridoxalated hemoglobin polyoxyethylene conjugate (n = 8). " 09/01/1997 - "Pyridoxalated hemoglobin polyoxyethylene conjugate does not restore hypoxic pulmonary vasoconstriction in ovine sepsis."
5.	Brain Ischemia (Cerebral Ischemia) 01/01/1997 - "The purpose of this study is to elucidate whether pyridoxalated hemoglobin polyoxyethylene conjugate solution (PHP) exerts neuro-projective effects against cerebral ischemia. "

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Oxygen (Dioxygen)
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Solutions
5.	Maltose
6.	stroma free hemoglobin

Related Therapies and Procedures

1.	Resuscitation