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ditekiren

orally active renin inhibitor

Also Known As:

Boc-Pro-Phe-N-MeHis-Leu(psi)(CHOHCH2)Val-Ile-2-aminomethylpyridine; U 71038; U-71038

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - ditekiren: 3

Related Diseases

1.	Ganglion Cysts (Ganglion) 12/01/1986 - "Enzyme kinetic studies indicated that U-71038 was a competitive inhibitor of hog renin with an inhibitor constant (Ki) value of 12 nM. Intravenous as well as oral administration of U-71038 to anesthetized, ganglion-blocked rats infused with hog renin elicited dose-related hypotensive responses. "
2.	Hypotension (Low Blood Pressure) 04/01/1989 - "A similar reduction in total peripheral resistance was observed after captopril at a dose which caused hypotension equivalent to that elicited by U-71038. " 12/01/1986 - "Similarly, the oral administration of U-71038 at 50 mg/kg to conscious, sodium-depleted monkeys elicited a pronounced hypotension and decrease in plasma renin activity that persisted for 5 hours. "
3.	Tachycardia (Tachyarrhythmias) 01/01/1991 - "An apparent over-additive hypotensive response, accompanied by tachycardia, occurred in sodium replete monkeys when ditekiren was administered after captopril. "

Related Drugs and Biologics

1.	Renin
2.	Enzymes
3.	Sodium
4.	Captopril (Capoten)

Related Therapies and Procedures

1.	Oral Administration